Age-related modifications of diffusion tensor imaging parameters and white matter hyperintensities as inter-dependent processes
Microstructural changes of White Matter (WM) associated with aging have been widely described through Diffusion Tensor Imaging (DTI) parameters. In parallel, White Matter Hyperintensities (WMH) as observed on a T2-MRI are extremely common in older individuals. However, few studies have investigated...
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doaj-3a12aab731b3473e94ab553cffddd2a02020-11-25T00:04:56ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652016-01-01710.3389/fnagi.2015.00255154972Age-related modifications of diffusion tensor imaging parameters and white matter hyperintensities as inter-dependent processesAmandine ePelletier0Olivier ePeriot1Bixente eDilharreguy2Bassem eHiba3Martine eBordessoules4Sandra eChanraud5Karine ePérès6Hélène eAmieva7Jean-François eDartigues8Michèle eAllard9Gwénäelle eCatheline10INCIA UMR 5287 CNRS - Université de BordeauxINCIA UMR 5287 CNRS - Université de BordeauxINCIA UMR 5287 CNRS - Université de BordeauxRMSB, UMR 5536 - Université de BordeauxINCIA UMR 5287 CNRS - Université de BordeauxINCIA UMR 5287 CNRS - Université de BordeauxISPED, Centre INSERM U897ISPED, Centre INSERM U897ISPED, Centre INSERM U897INCIA UMR 5287 CNRS - Université de BordeauxINCIA UMR 5287 CNRS - Université de BordeauxMicrostructural changes of White Matter (WM) associated with aging have been widely described through Diffusion Tensor Imaging (DTI) parameters. In parallel, White Matter Hyperintensities (WMH) as observed on a T2-MRI are extremely common in older individuals. However, few studies have investigated both phenomena conjointly. The present study investigates aging effects on DTI parameters in absence and in presence of WMH. Diffusion maps were constructed based on 21 directions DTI scans of young adults (n=19, mean age=33 SD=7.4) and two age-matched groups of older adults, one presenting low-level-WMH (n=20, mean age=78, SD= 3.2) and one presenting high-level-WMH (n=20, mean age=79, SD= 5.4). Older subjects with low-level-WMH presented modifications of DTI parameters in comparison to younger subjects, fitting with the DTI pattern classically described in aging, i.e. Fractional Anisotropy (FA) decrease/Radial Diffusivity (RD) increase. Furthermore, older subjects with high-level-WMH showed higher DTI modifications in Normal Appearing White Matter (NAWM) in comparison to those with low-level-WMH. Finally, in older subjects with high-level-WMH, FA or RD values of NAWM were associated with to WMH burden. Therefore, our findings suggest that DTI modifications and the presence of WMH would be two inter-dependent processes but occurring within different temporal windows. DTI changes would reflect the early phase of white matter changes and WMH would appear as a consequence of those changes.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00255/fullAgingDiffusion Tensor Imagingwhite matter hyperintensitiesnormal appearing white matterinter-dependent processes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Amandine ePelletier Olivier ePeriot Bixente eDilharreguy Bassem eHiba Martine eBordessoules Sandra eChanraud Karine ePérès Hélène eAmieva Jean-François eDartigues Michèle eAllard Gwénäelle eCatheline |
spellingShingle |
Amandine ePelletier Olivier ePeriot Bixente eDilharreguy Bassem eHiba Martine eBordessoules Sandra eChanraud Karine ePérès Hélène eAmieva Jean-François eDartigues Michèle eAllard Gwénäelle eCatheline Age-related modifications of diffusion tensor imaging parameters and white matter hyperintensities as inter-dependent processes Frontiers in Aging Neuroscience Aging Diffusion Tensor Imaging white matter hyperintensities normal appearing white matter inter-dependent processes |
author_facet |
Amandine ePelletier Olivier ePeriot Bixente eDilharreguy Bassem eHiba Martine eBordessoules Sandra eChanraud Karine ePérès Hélène eAmieva Jean-François eDartigues Michèle eAllard Gwénäelle eCatheline |
author_sort |
Amandine ePelletier |
title |
Age-related modifications of diffusion tensor imaging parameters and white matter hyperintensities as inter-dependent processes |
title_short |
Age-related modifications of diffusion tensor imaging parameters and white matter hyperintensities as inter-dependent processes |
title_full |
Age-related modifications of diffusion tensor imaging parameters and white matter hyperintensities as inter-dependent processes |
title_fullStr |
Age-related modifications of diffusion tensor imaging parameters and white matter hyperintensities as inter-dependent processes |
title_full_unstemmed |
Age-related modifications of diffusion tensor imaging parameters and white matter hyperintensities as inter-dependent processes |
title_sort |
age-related modifications of diffusion tensor imaging parameters and white matter hyperintensities as inter-dependent processes |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Aging Neuroscience |
issn |
1663-4365 |
publishDate |
2016-01-01 |
description |
Microstructural changes of White Matter (WM) associated with aging have been widely described through Diffusion Tensor Imaging (DTI) parameters. In parallel, White Matter Hyperintensities (WMH) as observed on a T2-MRI are extremely common in older individuals. However, few studies have investigated both phenomena conjointly. The present study investigates aging effects on DTI parameters in absence and in presence of WMH. Diffusion maps were constructed based on 21 directions DTI scans of young adults (n=19, mean age=33 SD=7.4) and two age-matched groups of older adults, one presenting low-level-WMH (n=20, mean age=78, SD= 3.2) and one presenting high-level-WMH (n=20, mean age=79, SD= 5.4). Older subjects with low-level-WMH presented modifications of DTI parameters in comparison to younger subjects, fitting with the DTI pattern classically described in aging, i.e. Fractional Anisotropy (FA) decrease/Radial Diffusivity (RD) increase. Furthermore, older subjects with high-level-WMH showed higher DTI modifications in Normal Appearing White Matter (NAWM) in comparison to those with low-level-WMH. Finally, in older subjects with high-level-WMH, FA or RD values of NAWM were associated with to WMH burden. Therefore, our findings suggest that DTI modifications and the presence of WMH would be two inter-dependent processes but occurring within different temporal windows. DTI changes would reflect the early phase of white matter changes and WMH would appear as a consequence of those changes. |
topic |
Aging Diffusion Tensor Imaging white matter hyperintensities normal appearing white matter inter-dependent processes |
url |
http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00255/full |
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