Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages.
Shigella infection, the cause of bacillary dysentery, induces caspase-1 activation and cell death in macrophages, but the precise mechanisms of this activation remain poorly understood. We demonstrate here that caspase-1 activation and IL-1beta processing induced by Shigella are mediated through Ipa...
Main Authors: | Toshihiko Suzuki, Luigi Franchi, Claudia Toma, Hiroshi Ashida, Michinaga Ogawa, Yuko Yoshikawa, Hitomi Mimuro, Naohiro Inohara, Chihiro Sasakawa, Gabriel Nuñez |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2007-08-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC1941748?pdf=render |
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