Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis.
In mouse senile amyloidosis, apolipoprotein (Apo) A-II is deposited extracellularly in many organs in the form of amyloid fibrils (AApoAII). Reduction of caloric intake, known as caloric restriction (CR), slows the progress of senescence and age-related disorders in mice. In this study, we intraveno...
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doaj-3a1a5edb80b9438cbffe94fe2cc334cd2020-11-25T01:48:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017240210.1371/journal.pone.0172402Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis.Lin LiJinko SawashitaXin DingMu YangZhe XuHiroki MiyaharaMasayuki MoriKeiichi HiguchiIn mouse senile amyloidosis, apolipoprotein (Apo) A-II is deposited extracellularly in many organs in the form of amyloid fibrils (AApoAII). Reduction of caloric intake, known as caloric restriction (CR), slows the progress of senescence and age-related disorders in mice. In this study, we intravenously injected 1 μg of isolated AApoAII fibrils into R1.P1-Apoa2c mice to induce experimental amyloidosis and investigated the effects of CR for the next 16 weeks. In the CR group, AApoAII amyloid deposits in the liver, tongue, small intestine and skin were significantly reduced compared to those of the ad libitum feeding group. CR treatment led to obvious reduction in body weight, improvement in glucose metabolism and reduction in the plasma concentration of ApoA-II. Our molecular biological analyses of the liver suggested that CR treatment might improve the symptoms of inflammation, the unfolded protein response induced by amyloid deposits and oxidative stress. Furthermore, we suggest that CR treatment might improve mitochondrial functions via the sirtuin 1-peroxisome proliferator-activated receptor γ coactivator 1α (SIRT1-PGC-1α) pathway. We suggest that CR is a promising approach for treating the onset and/or progression of amyloidosis, especially for systemic amyloidosis such as senile AApoAII amyloidosis. Our analysis of CR treatment for amyloidosis should provide useful information for determining the cause of amyloidosis and developing effective preventive treatments.http://europepmc.org/articles/PMC5321440?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lin Li Jinko Sawashita Xin Ding Mu Yang Zhe Xu Hiroki Miyahara Masayuki Mori Keiichi Higuchi |
spellingShingle |
Lin Li Jinko Sawashita Xin Ding Mu Yang Zhe Xu Hiroki Miyahara Masayuki Mori Keiichi Higuchi Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis. PLoS ONE |
author_facet |
Lin Li Jinko Sawashita Xin Ding Mu Yang Zhe Xu Hiroki Miyahara Masayuki Mori Keiichi Higuchi |
author_sort |
Lin Li |
title |
Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis. |
title_short |
Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis. |
title_full |
Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis. |
title_fullStr |
Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis. |
title_full_unstemmed |
Caloric restriction reduces the systemic progression of mouse AApoAII amyloidosis. |
title_sort |
caloric restriction reduces the systemic progression of mouse aapoaii amyloidosis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
In mouse senile amyloidosis, apolipoprotein (Apo) A-II is deposited extracellularly in many organs in the form of amyloid fibrils (AApoAII). Reduction of caloric intake, known as caloric restriction (CR), slows the progress of senescence and age-related disorders in mice. In this study, we intravenously injected 1 μg of isolated AApoAII fibrils into R1.P1-Apoa2c mice to induce experimental amyloidosis and investigated the effects of CR for the next 16 weeks. In the CR group, AApoAII amyloid deposits in the liver, tongue, small intestine and skin were significantly reduced compared to those of the ad libitum feeding group. CR treatment led to obvious reduction in body weight, improvement in glucose metabolism and reduction in the plasma concentration of ApoA-II. Our molecular biological analyses of the liver suggested that CR treatment might improve the symptoms of inflammation, the unfolded protein response induced by amyloid deposits and oxidative stress. Furthermore, we suggest that CR treatment might improve mitochondrial functions via the sirtuin 1-peroxisome proliferator-activated receptor γ coactivator 1α (SIRT1-PGC-1α) pathway. We suggest that CR is a promising approach for treating the onset and/or progression of amyloidosis, especially for systemic amyloidosis such as senile AApoAII amyloidosis. Our analysis of CR treatment for amyloidosis should provide useful information for determining the cause of amyloidosis and developing effective preventive treatments. |
url |
http://europepmc.org/articles/PMC5321440?pdf=render |
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