No associations in preregistered study of youth depression and functional connectivity of fronto-parietal and default mode networks
Adolescence is characterized by vulnerability to the onset of major depressive disorder (MDD). The goal of this preregistered study was to assess neural correlates of depression symptoms in young adolescents, both cross-sectionally and longitudinally. The default mode network (DMN) is believed to su...
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doaj-3a213de75b114b21a257841d8ca460532021-08-02T04:42:47ZengElsevierNeuroimage: Reports2666-95602021-09-0113100036No associations in preregistered study of youth depression and functional connectivity of fronto-parietal and default mode networksYueyue Qu0Brent I. Rappaport1Joan L. Luby2Deanna M. Barch3Department of Psychological & Brain Sciences, Washington University in St. Louis, One Brookings Drive, St. Louis, MO, 63105, USA; Corresponding author.Department of Psychological & Brain Sciences, Washington University in St. Louis, One Brookings Drive, St. Louis, MO, 63105, USADepartment of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO, 63110, USADepartment of Psychological & Brain Sciences, Washington University in St. Louis, One Brookings Drive, St. Louis, MO, 63105, USA; Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO, 63110, USA; Department of Radiology, Washington University School of Medicine, 660 S. Euclid Avenue, St. Louis, MO, 63110, USAAdolescence is characterized by vulnerability to the onset of major depressive disorder (MDD). The goal of this preregistered study was to assess neural correlates of depression symptoms in young adolescents, both cross-sectionally and longitudinally. The default mode network (DMN) is believed to support internal attention towards self-referential thoughts, while the fronto-parietal network (FPN) is theorized to support cognitive control and regulation of attention. As MDD diagnosis has been associated with heightened connectivity within DMN regions and diminished connectivity within FPN regions relative to healthy controls, our study builds upon group-difference analyses by using dimensional measures of depression severity. Our preregistered hypotheses were that within-DMN functional connectivity would be positively associated with concurrent depression severity, while within-FPN functional connectivity would be negatively associated with concurrent depression severity. Preregistered analyses also examined between DMN-FPN connectivity as an alternative predictor variable, and assessed the longitudinal associations between all three functional connectivity measures and change in depression severity over three subsequent waves. Multiple regression models tested cross-sectional analyses and hierarchical linear models tested longitudinal analyses. One hundred and twenty-four youth completed a resting state functional MRI. Their depression severity was assessed at the time of the scan and at three follow-up sessions. None of the predictor variables were associated with concurrent depression severity, nor with the slope of depression symptom trajectories in longitudinal analyses. These negative results add to extant cross-sectional studies, and may inform future investigations of brain correlates of depression psychopathology in youth.http://www.sciencedirect.com/science/article/pii/S2666956021000349AdolescenceDepressionLongitudinalBrain developmentResting state MRI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yueyue Qu Brent I. Rappaport Joan L. Luby Deanna M. Barch |
spellingShingle |
Yueyue Qu Brent I. Rappaport Joan L. Luby Deanna M. Barch No associations in preregistered study of youth depression and functional connectivity of fronto-parietal and default mode networks Neuroimage: Reports Adolescence Depression Longitudinal Brain development Resting state MRI |
author_facet |
Yueyue Qu Brent I. Rappaport Joan L. Luby Deanna M. Barch |
author_sort |
Yueyue Qu |
title |
No associations in preregistered study of youth depression and functional connectivity of fronto-parietal and default mode networks |
title_short |
No associations in preregistered study of youth depression and functional connectivity of fronto-parietal and default mode networks |
title_full |
No associations in preregistered study of youth depression and functional connectivity of fronto-parietal and default mode networks |
title_fullStr |
No associations in preregistered study of youth depression and functional connectivity of fronto-parietal and default mode networks |
title_full_unstemmed |
No associations in preregistered study of youth depression and functional connectivity of fronto-parietal and default mode networks |
title_sort |
no associations in preregistered study of youth depression and functional connectivity of fronto-parietal and default mode networks |
publisher |
Elsevier |
series |
Neuroimage: Reports |
issn |
2666-9560 |
publishDate |
2021-09-01 |
description |
Adolescence is characterized by vulnerability to the onset of major depressive disorder (MDD). The goal of this preregistered study was to assess neural correlates of depression symptoms in young adolescents, both cross-sectionally and longitudinally. The default mode network (DMN) is believed to support internal attention towards self-referential thoughts, while the fronto-parietal network (FPN) is theorized to support cognitive control and regulation of attention. As MDD diagnosis has been associated with heightened connectivity within DMN regions and diminished connectivity within FPN regions relative to healthy controls, our study builds upon group-difference analyses by using dimensional measures of depression severity. Our preregistered hypotheses were that within-DMN functional connectivity would be positively associated with concurrent depression severity, while within-FPN functional connectivity would be negatively associated with concurrent depression severity. Preregistered analyses also examined between DMN-FPN connectivity as an alternative predictor variable, and assessed the longitudinal associations between all three functional connectivity measures and change in depression severity over three subsequent waves. Multiple regression models tested cross-sectional analyses and hierarchical linear models tested longitudinal analyses. One hundred and twenty-four youth completed a resting state functional MRI. Their depression severity was assessed at the time of the scan and at three follow-up sessions. None of the predictor variables were associated with concurrent depression severity, nor with the slope of depression symptom trajectories in longitudinal analyses. These negative results add to extant cross-sectional studies, and may inform future investigations of brain correlates of depression psychopathology in youth. |
topic |
Adolescence Depression Longitudinal Brain development Resting state MRI |
url |
http://www.sciencedirect.com/science/article/pii/S2666956021000349 |
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