Verbal Memory Performance in Depressed Children and Adolescents: Associations with EPA but Not DHA and Depression Severity
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been described as positively associated with cognitive functioning. Current meta-analyses have identified eicosapentaenoic acid (EPA) as potentially more effective than docosahexaenoic acid (DHA). An especially vulnerable subgroup that might benef...
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doaj-3a2a64a9f60940779c0b34a48f97949e2020-11-27T08:05:02ZengMDPI AGNutrients2072-66432020-11-01123630363010.3390/nu12123630Verbal Memory Performance in Depressed Children and Adolescents: Associations with EPA but Not DHA and Depression SeveritySophie Emery0Isabelle Häberling1Gregor Berger2Noemi Baumgartner3Michael Strumberger4Mona Albermann5Kristin Nalani6Klaus Schmeck7Suzanne Erb8Silke Bachmann9Lars Wöckel10Ulrich Müller-Knapp11Brigitte Contin-Waldvogel12Bruno Rhiner13Susanne Walitza14Martin Hersberger15Renate Drechsler16Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, 8032 Zurich, SwitzerlandDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, 8032 Zurich, SwitzerlandDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, 8032 Zurich, SwitzerlandDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, 8032 Zurich, SwitzerlandResearch Department of Child and Adolescent Psychiatry, Psychiatric University Hospitals Basel, University of Basel, 4002 Basel, SwitzerlandDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, 8032 Zurich, SwitzerlandClinic for Psychosomatic Medicine and Psychiatry, University Hospital Zurich, 8091 Zurich, SwitzerlandResearch Department of Child and Adolescent Psychiatry, Psychiatric University Hospitals Basel, University of Basel, 4002 Basel, SwitzerlandChild and Adolescent Psychiatric Services St. Gallen, 9004 St. Gallen, SwitzerlandDepartment of Psychiatry, University Hospitals of Geneva, 1226 Thônex, SwitzerlandResearch Department of Child and Adolescent Psychiatry, Psychiatric University Hospitals Basel, University of Basel, 4002 Basel, SwitzerlandChild and Adolescent Psychiatry Klinik Sonnenhof, 9608 Ganterschwil, SwitzerlandChild and Adolescent Psychiatric Services Baselland, 4410 Liestal, SwitzerlandChild and Adolescent Psychiatric Services Thurgau, 8570 Weinfelden, SwitzerlandDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, 8032 Zurich, SwitzerlandCenter for Integrative Human Physiology Zurich, University of Zurich, 8057 Zurich, SwitzerlandDepartment of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, 8032 Zurich, SwitzerlandOmega-3 polyunsaturated fatty acids (n-3 PUFAs) have been described as positively associated with cognitive functioning. Current meta-analyses have identified eicosapentaenoic acid (EPA) as potentially more effective than docosahexaenoic acid (DHA). An especially vulnerable subgroup that might benefit from these beneficial effects are depressed youths. In this study, we examined associations between red blood cell (RBC) DHA and EPA levels and depression severity and verbal memory performance in a sample of 107 moderately (<i>n</i> = 63) and severely (<i>n</i> = 44) depressed youths. The findings showed that youths with high RBC EPA levels had steeper learning curves compared to those with moderate or low RBC EPA levels (Pillai’s Trace = 0.195, <i>p</i> = 0.027, η<sub>p</sub><sup>2</sup> = 0.097). No associations between RBC DHA levels or depression severity and verbal memory performance were observed. Our results further confirm previous findings indicating a more important role of EPA compared to DHA in relation to cognitive functioning. Future research should further investigate the differential role of EPA and DHA concerning cognitive functioning in depressed youths. Evidence supporting beneficial supplementation effects could potentially establish a recommendation for a natural and easily accessible intervention for cognitive improvement or remission.https://www.mdpi.com/2072-6643/12/12/3630omega-3 polyunsaturated fatty acidEPADHAdepressiondepression severityverbal memory |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sophie Emery Isabelle Häberling Gregor Berger Noemi Baumgartner Michael Strumberger Mona Albermann Kristin Nalani Klaus Schmeck Suzanne Erb Silke Bachmann Lars Wöckel Ulrich Müller-Knapp Brigitte Contin-Waldvogel Bruno Rhiner Susanne Walitza Martin Hersberger Renate Drechsler |
spellingShingle |
Sophie Emery Isabelle Häberling Gregor Berger Noemi Baumgartner Michael Strumberger Mona Albermann Kristin Nalani Klaus Schmeck Suzanne Erb Silke Bachmann Lars Wöckel Ulrich Müller-Knapp Brigitte Contin-Waldvogel Bruno Rhiner Susanne Walitza Martin Hersberger Renate Drechsler Verbal Memory Performance in Depressed Children and Adolescents: Associations with EPA but Not DHA and Depression Severity Nutrients omega-3 polyunsaturated fatty acid EPA DHA depression depression severity verbal memory |
author_facet |
Sophie Emery Isabelle Häberling Gregor Berger Noemi Baumgartner Michael Strumberger Mona Albermann Kristin Nalani Klaus Schmeck Suzanne Erb Silke Bachmann Lars Wöckel Ulrich Müller-Knapp Brigitte Contin-Waldvogel Bruno Rhiner Susanne Walitza Martin Hersberger Renate Drechsler |
author_sort |
Sophie Emery |
title |
Verbal Memory Performance in Depressed Children and Adolescents: Associations with EPA but Not DHA and Depression Severity |
title_short |
Verbal Memory Performance in Depressed Children and Adolescents: Associations with EPA but Not DHA and Depression Severity |
title_full |
Verbal Memory Performance in Depressed Children and Adolescents: Associations with EPA but Not DHA and Depression Severity |
title_fullStr |
Verbal Memory Performance in Depressed Children and Adolescents: Associations with EPA but Not DHA and Depression Severity |
title_full_unstemmed |
Verbal Memory Performance in Depressed Children and Adolescents: Associations with EPA but Not DHA and Depression Severity |
title_sort |
verbal memory performance in depressed children and adolescents: associations with epa but not dha and depression severity |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-11-01 |
description |
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have been described as positively associated with cognitive functioning. Current meta-analyses have identified eicosapentaenoic acid (EPA) as potentially more effective than docosahexaenoic acid (DHA). An especially vulnerable subgroup that might benefit from these beneficial effects are depressed youths. In this study, we examined associations between red blood cell (RBC) DHA and EPA levels and depression severity and verbal memory performance in a sample of 107 moderately (<i>n</i> = 63) and severely (<i>n</i> = 44) depressed youths. The findings showed that youths with high RBC EPA levels had steeper learning curves compared to those with moderate or low RBC EPA levels (Pillai’s Trace = 0.195, <i>p</i> = 0.027, η<sub>p</sub><sup>2</sup> = 0.097). No associations between RBC DHA levels or depression severity and verbal memory performance were observed. Our results further confirm previous findings indicating a more important role of EPA compared to DHA in relation to cognitive functioning. Future research should further investigate the differential role of EPA and DHA concerning cognitive functioning in depressed youths. Evidence supporting beneficial supplementation effects could potentially establish a recommendation for a natural and easily accessible intervention for cognitive improvement or remission. |
topic |
omega-3 polyunsaturated fatty acid EPA DHA depression depression severity verbal memory |
url |
https://www.mdpi.com/2072-6643/12/12/3630 |
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