Comparison of direct oral anticoagulants and warfarin regarding midterm adverse events in patients with atrial fibrillation undergoing catheter ablation

• Main Authors: Yuichiro Sagawa, Yasutoshi Nagata, Tetsuo Yamaguchi, Takamasa Iwai, Junji Yamaguchi, Sadahiro Hijikata, Keita Watanabe, Ryo Masuda, Ryoichi Miyazaki, Naoyuki Miwa, Masahiro Sekigawa, Nobuhiro Hara, Toshihiro Nozato, Kenzo Hirao
• Format: Article
• Language: English
• Published: Wiley 2018-08-01
• Series: Journal of Arrhythmia
• Subjects: atrial fibrillation; catheter ablation; complication; direct oral anticoagulants; warfarin
• Online Access: https://doi.org/10.1002/joa3.12079
• ISSN: 1880-4276; 1883-2148

Abstract Background Oral anticoagulants, including direct oral anticoagulants (DOACs), are usually required in atrial fibrillation (AF) patients who are at a high risk of thromboembolism (TE), even if they had undergone catheter ablation (CA). Although several studies have reported the safety and efficacy of DOACs around CA in AF patients, there are only limited data regarding the midterm incidence of TE and bleeding complications post‐CA among AF patients treated with warfarin or DOACs. Methods We studied 629 AF patients (mean age: 65.3 ± 10.3 years; 442 men) undergoing CA, to calculate the midterm incidence of TE and bleeding complications associated with warfarin or DOACs. Results In total, 292 patients used warfarin and 337 used DOACs (dabigatran: 90 patients; rivaroxaban: 137; and apixaban: 110). At baseline, the CHA2DS2‐VASc and HAS‐BLED scores were similar between the 2 groups. During a median follow‐up period of 7 months, no TE complications occurred. The warfarin group had a significantly higher bleeding event rate than did the DOACs group (all bleeding complications: 32 [11.0%] vs 15 [4.5%], respectively, P = .002). The rate of all bleeding complications was significantly higher in the warfarin group than in the DOACs group (10.1% vs 3.7%, respectively, at 10 months; P = .024). In Cox proportional hazards modeling, DOAC use was significantly associated with a decreased risk of bleeding (adjusted hazard ratio: 0.497; 95% confidence interval: 0.261‐0.906, P = .022). Conclusions Direct oral anticoagulant use in AF patients undergoing CA may be associated with a similar risk of TE as warfarin but is associated with a lower risk of bleeding.