The role of the TNF receptors and apoptosis inducing ligands in tumor growth
Tumor necrosis factor (TNF) superfamily receptors and TNF apoptosis inducing ligands play an important role in the realization of TNF function and control tumor growth. The TNF-related pathways are controlled by endoplasmic reticulum stress signaling, which has a crucial role in the control of cell...
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National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
2016-10-01
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doaj-3a3b071dfd1b42ad98b2d5584f8067a52020-11-24T22:46:50ZengNational Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.Ukrainian Biochemical Journal2413-50032016-10-01885183710.15407/ubj88.05.018The role of the TNF receptors and apoptosis inducing ligands in tumor growthO. H. Minchenko10D. O. Tsymbal11D. O. Minchenko1,2,2 О. O. Ratushna13Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;2Bohomolets National Medical University, Kyiv, UkrainPalladin Institute of Biochemistry, NationalAcademy of Sciences of Ukraine, Kyiv ; Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;Tumor necrosis factor (TNF) superfamily receptors and TNF apoptosis inducing ligands play an important role in the realization of TNF function and control tumor growth. The TNF-related pathways are controlled by endoplasmic reticulum stress signaling, which has a crucial role in the control of cell proliferation and tumor growth. Furthermore, the inhibition of IRE1 (inositol requiring enzyme-1), which is a central mediator of endoplasmic reticulum stress sand mainly responsible for cell proliferation and apoptosis, leads to suppression of tumor growth through specific changes in the expression of genes encoding transcription factors, tumor suppressors, angiogenesis and apoptosis related proteins, including TNF superfamily receptors and TNF apoptosis inducing ligands. Therefore, changes in the expression level of TNF-related genes encoding TNF superfamily receptors and apoptosis inducing ligands possibly reflect metabolic reprogramming of cancer cells upon inhibition of IRE1-mediated endoplasmic reticulum stress signaling and correlate with suppression of glioma cell proliferation.http://ukrbiochemjournal.org/wp-content/uploads/2016/11/Minchenko_5_16.pdfdecoy receptorsglioma cellsIRE1 inhibitionTNF superfamily receptorsTRAIL |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
O. H. Minchenko1 D. O. Tsymbal1 D. O. Minchenko1,2, О. O. Ratushna1 |
spellingShingle |
O. H. Minchenko1 D. O. Tsymbal1 D. O. Minchenko1,2, О. O. Ratushna1 The role of the TNF receptors and apoptosis inducing ligands in tumor growth Ukrainian Biochemical Journal decoy receptors glioma cells IRE1 inhibition TNF superfamily receptors TRAIL |
author_facet |
O. H. Minchenko1 D. O. Tsymbal1 D. O. Minchenko1,2, О. O. Ratushna1 |
author_sort |
O. H. Minchenko1 |
title |
The role of the TNF receptors and apoptosis inducing ligands in tumor growth |
title_short |
The role of the TNF receptors and apoptosis inducing ligands in tumor growth |
title_full |
The role of the TNF receptors and apoptosis inducing ligands in tumor growth |
title_fullStr |
The role of the TNF receptors and apoptosis inducing ligands in tumor growth |
title_full_unstemmed |
The role of the TNF receptors and apoptosis inducing ligands in tumor growth |
title_sort |
role of the tnf receptors and apoptosis inducing ligands in tumor growth |
publisher |
National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. |
series |
Ukrainian Biochemical Journal |
issn |
2413-5003 |
publishDate |
2016-10-01 |
description |
Tumor necrosis factor (TNF) superfamily receptors and TNF apoptosis inducing ligands play an important role in the realization of TNF function and control tumor growth. The TNF-related pathways are controlled by endoplasmic reticulum stress signaling, which has a crucial role in the control of cell proliferation and tumor growth. Furthermore, the inhibition of IRE1 (inositol requiring enzyme-1), which is a central mediator of endoplasmic reticulum stress sand mainly responsible for cell proliferation and apoptosis, leads to suppression of tumor growth through specific changes in the expression of genes encoding transcription factors, tumor suppressors, angiogenesis and apoptosis related proteins, including TNF superfamily receptors and TNF apoptosis inducing ligands. Therefore, changes in the expression level of TNF-related genes encoding TNF superfamily receptors and apoptosis inducing ligands possibly reflect metabolic reprogramming of cancer cells upon inhibition of IRE1-mediated endoplasmic reticulum stress signaling and correlate with suppression of glioma cell proliferation. |
topic |
decoy receptors glioma cells IRE1 inhibition TNF superfamily receptors TRAIL |
url |
http://ukrbiochemjournal.org/wp-content/uploads/2016/11/Minchenko_5_16.pdf |
work_keys_str_mv |
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