Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease
Objectives: Osteoporosis is commonly developed due tonatural course of Behçet’s disease (BD) and therapeuticagents. It was aimed to investigate levels of osteoprotegerinand TNF-α (tumor necrosis factor), and bone mineral density(BMD) and correlation between them in BD.Materials and methods: The stud...
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doaj-3a3ded3146b54cff8846b12a649d78bf2020-11-25T00:04:09ZengDicle University Medical SchoolDicle Medical Journal 1300-29451308-98892012-09-01393325330Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s DiseaseAli KutlucanSevket Ercan TuncDavut BaltacıMehmet SahinMustafa OzsahinRecep SütcüFatih ErmisHarun SüslüObjectives: Osteoporosis is commonly developed due tonatural course of Behçet’s disease (BD) and therapeuticagents. It was aimed to investigate levels of osteoprotegerinand TNF-α (tumor necrosis factor), and bone mineral density(BMD) and correlation between them in BD.Materials and methods: The study included two groupsas the study and the control group. Serum levels of TNF-α,osteoprotegerin, osteocalcine, erythrocyte sedimentation rate(ESR), C-reactive protein (CRP), and urinary creatinine anddeoxypyridinoline along with BMD level were evaluated andcompared. Correlation between TNF-α and osteoprotegerinlevel was investigated.Results: The study enrolled 41 BD patients and 36 agedmatchedcontrol subjects. Mean age was 42.26±11.64 and41.66±70.99, in the study and control groups, respectively.There was no significant difference in body mass index(BMI) of subjects between groups (p>0.05). Level of TNF-α(p<0.001), deoxypyridinoline (p<0.001) and osteocalcine(p=0.041) was significantly higher in the study group comparedto the control group. Osteoprotegerin was lower inBD patients, but the difference was not significant (p>0.05).Urinary deoxypyridinoline/ urinary creatinine ratio in patientswith BD was significantly higher than those in control group(p=0.030). Patients had significantly lower BMD comparfedto the control group, except L2-L4 vertebral area (p<0.001,p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 andp=0.111, respectively). No correlation was found betweenTNF-α and osteoprotegerin.Conclusions: The present study indicated that TNF-α andBMD was negatively correlated with each other and TNF-αhad an effect on osteoporotic process in patients with BD.Osteoprotegerin level was not decreased, and not correlatedwith TNF-α.Key words: Behçet’s disease, osteoprotegerin, TNF-α, osteocalcinehttp://diclemedj.org/upload/sayi/3/Dicle%20Med%20J-01214.pdfBehçet’s diseaseosteoprotegerinTNF-αosteocalcine |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ali Kutlucan Sevket Ercan Tunc Davut Baltacı Mehmet Sahin Mustafa Ozsahin Recep Sütcü Fatih Ermis Harun Süslü |
spellingShingle |
Ali Kutlucan Sevket Ercan Tunc Davut Baltacı Mehmet Sahin Mustafa Ozsahin Recep Sütcü Fatih Ermis Harun Süslü Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease Dicle Medical Journal Behçet’s disease osteoprotegerin TNF-α osteocalcine |
author_facet |
Ali Kutlucan Sevket Ercan Tunc Davut Baltacı Mehmet Sahin Mustafa Ozsahin Recep Sütcü Fatih Ermis Harun Süslü |
author_sort |
Ali Kutlucan |
title |
Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease |
title_short |
Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease |
title_full |
Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease |
title_fullStr |
Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease |
title_full_unstemmed |
Serum levels of TNF-α and osteoprotegerin and bone mineral density in patients with Behçet’s Disease |
title_sort |
serum levels of tnf-α and osteoprotegerin and bone mineral density in patients with behçet’s disease |
publisher |
Dicle University Medical School |
series |
Dicle Medical Journal |
issn |
1300-2945 1308-9889 |
publishDate |
2012-09-01 |
description |
Objectives: Osteoporosis is commonly developed due tonatural course of Behçet’s disease (BD) and therapeuticagents. It was aimed to investigate levels of osteoprotegerinand TNF-α (tumor necrosis factor), and bone mineral density(BMD) and correlation between them in BD.Materials and methods: The study included two groupsas the study and the control group. Serum levels of TNF-α,osteoprotegerin, osteocalcine, erythrocyte sedimentation rate(ESR), C-reactive protein (CRP), and urinary creatinine anddeoxypyridinoline along with BMD level were evaluated andcompared. Correlation between TNF-α and osteoprotegerinlevel was investigated.Results: The study enrolled 41 BD patients and 36 agedmatchedcontrol subjects. Mean age was 42.26±11.64 and41.66±70.99, in the study and control groups, respectively.There was no significant difference in body mass index(BMI) of subjects between groups (p>0.05). Level of TNF-α(p<0.001), deoxypyridinoline (p<0.001) and osteocalcine(p=0.041) was significantly higher in the study group comparedto the control group. Osteoprotegerin was lower inBD patients, but the difference was not significant (p>0.05).Urinary deoxypyridinoline/ urinary creatinine ratio in patientswith BD was significantly higher than those in control group(p=0.030). Patients had significantly lower BMD comparfedto the control group, except L2-L4 vertebral area (p<0.001,p<0.001, p=0.035, p<0.001, p=0.012, p<0.001, p<0.001 andp=0.111, respectively). No correlation was found betweenTNF-α and osteoprotegerin.Conclusions: The present study indicated that TNF-α andBMD was negatively correlated with each other and TNF-αhad an effect on osteoporotic process in patients with BD.Osteoprotegerin level was not decreased, and not correlatedwith TNF-α.Key words: Behçet’s disease, osteoprotegerin, TNF-α, osteocalcine |
topic |
Behçet’s disease osteoprotegerin TNF-α osteocalcine |
url |
http://diclemedj.org/upload/sayi/3/Dicle%20Med%20J-01214.pdf |
work_keys_str_mv |
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