Two cases of hand, foot and mouth disease caused by enterovirus A71 after vaccination
Background: Enterovirus A71 (EVA71) is one of the main pathogens causing hand, foot and mouth disease (HFMD). In China, the proportion of cases of HFMD caused by EVA71 is known to be significantly lower following EVA71 vaccination; however, infection with EVA71 can still occur after vaccination. Met...
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Format: | Article |
Language: | English |
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Elsevier
2021-07-01
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Series: | International Journal of Infectious Diseases |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221002575 |
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doaj-3a44ea454e464807982cb04cb2b4bc08 |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jiaolian Tang Zhilei Zhang Zhen Zhang Hailing Huang Tingyi Du Xiaodan Wang Lingmei Yan Qin Rao Jinghui Yang Meifeng Wang Ru Shen Qiangming Sun Hongchao Jiang |
spellingShingle |
Jiaolian Tang Zhilei Zhang Zhen Zhang Hailing Huang Tingyi Du Xiaodan Wang Lingmei Yan Qin Rao Jinghui Yang Meifeng Wang Ru Shen Qiangming Sun Hongchao Jiang Two cases of hand, foot and mouth disease caused by enterovirus A71 after vaccination International Journal of Infectious Diseases Enterovirus A71 Hand, foot and mouth disease Vaccination |
author_facet |
Jiaolian Tang Zhilei Zhang Zhen Zhang Hailing Huang Tingyi Du Xiaodan Wang Lingmei Yan Qin Rao Jinghui Yang Meifeng Wang Ru Shen Qiangming Sun Hongchao Jiang |
author_sort |
Jiaolian Tang |
title |
Two cases of hand, foot and mouth disease caused by enterovirus A71 after vaccination |
title_short |
Two cases of hand, foot and mouth disease caused by enterovirus A71 after vaccination |
title_full |
Two cases of hand, foot and mouth disease caused by enterovirus A71 after vaccination |
title_fullStr |
Two cases of hand, foot and mouth disease caused by enterovirus A71 after vaccination |
title_full_unstemmed |
Two cases of hand, foot and mouth disease caused by enterovirus A71 after vaccination |
title_sort |
two cases of hand, foot and mouth disease caused by enterovirus a71 after vaccination |
publisher |
Elsevier |
series |
International Journal of Infectious Diseases |
issn |
1201-9712 |
publishDate |
2021-07-01 |
description |
Background: Enterovirus A71 (EVA71) is one of the main pathogens causing hand, foot and mouth disease (HFMD). In China, the proportion of cases of HFMD caused by EVA71 is known to be significantly lower following EVA71 vaccination; however, infection with EVA71 can still occur after vaccination. Methods: The complete genomic sequences of EVA71-KM18A and KM18B (from two rare cases of EVA71 infection following vaccination) were obtained. Phylogenetic analysis, nucleotide mutation analysis, recombinant analysis and comparative analysis of amino acid mutations were performed. Results: Phylogenetic analysis determined that the EVA71 strains belonged to the C4a subgenotype. The KM18A and KM18B strains were highly similar to the vaccine strains. For the KM18B strain, there were some obvious homologous recombination signals in the 5’non-coding region, region 2A, region 2C and region 3D. Amino acid mutations were observed in the SP55 (position 729) and 71-6 (position 500) conformational neutralizing epitopes of the KM18A and KM18B strains. Conclusions: These amino acid mutations may affect the SP55 and 71-6 conformational neutralizing epitopes and change their spatial conformation, thereby weakening vaccine effectiveness. |
topic |
Enterovirus A71 Hand, foot and mouth disease Vaccination |
url |
http://www.sciencedirect.com/science/article/pii/S1201971221002575 |
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doaj-3a44ea454e464807982cb04cb2b4bc082021-07-23T04:47:12ZengElsevierInternational Journal of Infectious Diseases1201-97122021-07-01108190197Two cases of hand, foot and mouth disease caused by enterovirus A71 after vaccinationJiaolian Tang0Zhilei Zhang1Zhen Zhang2Hailing Huang3Tingyi Du4Xiaodan Wang5Lingmei Yan6Qin Rao7Jinghui Yang8Meifeng Wang9Ru Shen10Qiangming Sun11Hongchao Jiang12Institute of Paediatrics, The Kunming Children’s Hospital of Kunming Medical University, Kunming, PR China; Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, PR ChinaInstitute of Paediatrics, The Kunming Children’s Hospital of Kunming Medical University, Kunming, PR ChinaInstitute of Paediatrics, The Kunming Children’s Hospital of Kunming Medical University, Kunming, PR China; Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, PR ChinaDepartment of Laboratory, The Kunming Children’s Hospital, Kunming, PR ChinaDepartment of Laboratory, The Kunming Children’s Hospital, Kunming, PR ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, PR China; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, PR ChinaInstitute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, PR China; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, PR ChinaInstitute of Paediatrics, The Kunming Children’s Hospital of Kunming Medical University, Kunming, PR ChinaDepartment of Paediatrics, The First People’s Hospital of Yunnan Province, Kunming, PR ChinaInstitute of Paediatrics, The Kunming Children’s Hospital of Kunming Medical University, Kunming, PR ChinaDepartment of Laboratory, The Kunming Children’s Hospital, Kunming, PR China; Corresponding authors at: The Affiliated Children’s Hospital of Kunming Medical University, 288 Qian Xin Road, Kunming, Yunnan Province 650228, PR China.Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, PR China; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, PR China; Corresponding author at: Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, 935 Jiao Ling Road, Kunming, Yunnan Province 650118, PR China.Institute of Paediatrics, The Kunming Children’s Hospital of Kunming Medical University, Kunming, PR China; Yunnan Key Laboratory of Children’s Major Disease Research, Kunming, PR China; Corresponding authors at: The Affiliated Children’s Hospital of Kunming Medical University, 288 Qian Xin Road, Kunming, Yunnan Province 650228, PR China.Background: Enterovirus A71 (EVA71) is one of the main pathogens causing hand, foot and mouth disease (HFMD). In China, the proportion of cases of HFMD caused by EVA71 is known to be significantly lower following EVA71 vaccination; however, infection with EVA71 can still occur after vaccination. Methods: The complete genomic sequences of EVA71-KM18A and KM18B (from two rare cases of EVA71 infection following vaccination) were obtained. Phylogenetic analysis, nucleotide mutation analysis, recombinant analysis and comparative analysis of amino acid mutations were performed. Results: Phylogenetic analysis determined that the EVA71 strains belonged to the C4a subgenotype. The KM18A and KM18B strains were highly similar to the vaccine strains. For the KM18B strain, there were some obvious homologous recombination signals in the 5’non-coding region, region 2A, region 2C and region 3D. Amino acid mutations were observed in the SP55 (position 729) and 71-6 (position 500) conformational neutralizing epitopes of the KM18A and KM18B strains. Conclusions: These amino acid mutations may affect the SP55 and 71-6 conformational neutralizing epitopes and change their spatial conformation, thereby weakening vaccine effectiveness.http://www.sciencedirect.com/science/article/pii/S1201971221002575Enterovirus A71Hand, foot and mouth diseaseVaccination |