Pituitary Adenylate Cyclase Activating Peptide (1-38) and its analog (Acetyl-[Ala15, Ala20] PACAP 38-polyamide) reverse methacholine airway hyperresponsiveness in rats

Pituitary Adenylate Cyclase Activating Peptide (1-38) and its analog (Acetyl-[Ala15, Ala20] PACAP 38-polyamide) reverse methacholine airway hyperresponsiveness in rats

The aim of this study was to investigate both functionally and structurally bronchodilator effects of Pituitary adenylate cyclase activating peptide (PACAP38) and acetyl-[Ala15, Ala20] PACAP38-polyamide, a potent PACAP38 analog, in rats challenged by methacholine (MeCh). Male Wistar rats were divide...

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Bibliographic Details
Main Authors: Mounira Tlili, Sonia Rouatbi, Fedoua Gandia, Dorsaf Hallegue, Badreddine Sriha, Mohamed Taher Yacoubi, Raja Krichah, Mohsen Sakly, Khémais Ben Rhouma, David Vaudry, Olivier Wurtz, Olfa Tebourbi
Format: Article
Language:English
Published: Universidade de São Paulo 2015-09-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Adenilato cilase da pituitária/efeitos/doença pulmonar inflamatória
Adenilato cilase da pituitária/análogos/efeitos em doença pulmonar inflamatória
Metacolina
Resistência pulmonar
Broncodilatores/efeitos
Doenças pulmonares inflamatórias/tratamento
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300681&lng=en&tlng=en

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