Hypoxia-Targeted Drug Q6 Induces G2-M Arrest and Apoptosis via Poisoning Topoisomerase II under Hypoxia.
In spite of the tremendous efforts dedicated to developing hypoxia-activated prodrugs, no agents yet have been approved for clinical therapy. In the present study, the hypoxic selective anti-cancer activity as well as the cellular target of a novel tirapazamine (TPZ) analogue, 7-methyl-3-(3-chloroph...
Main Authors: | Linlin Chang, Xiaowen Liu, Dandan Wang, Jian Ma, Tianyi Zhou, Ying Chen, Rong Sheng, Yongzhou Hu, Ying Du, Qiaojun He, Bo Yang, Hong Zhu |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4674137?pdf=render |
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