Cochlear Sox2+ Glial Cells Are Potent Progenitors for Spiral Ganglion Neuron Reprogramming Induced by Small Molecules

Cochlear Sox2+ Glial Cells Are Potent Progenitors for Spiral Ganglion Neuron Reprogramming Induced by Small Molecules

In the mammalian cochlea, spiral ganglion neurons (SGNs) relay the acoustic information to the central auditory circuits. Degeneration of SGNs is a major cause of sensorineural hearing loss and severely affects the effectiveness of cochlear implant therapy. Cochlear glial cells are able to form sphe...

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Bibliographic Details
Main Authors: Zhen Chen, Yuhang Huang, Chaorong Yu, Qing Liu, Cui Qiu, Guoqiang Wan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
Sox2+ glial cells
glia-to-neuron conversion
small molecules reprogramming
SGN regeneration
lineage tracing
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.728352/full

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