Sphingolipid Metabolism in Glioblastoma and Metastatic Brain Tumors: A Review of Sphingomyelinases and Sphingosine-1-Phosphate

Sphingolipid Metabolism in Glioblastoma and Metastatic Brain Tumors: A Review of Sphingomyelinases and Sphingosine-1-Phosphate

Glioblastoma (GBM) is a primary malignant brain tumor with a dismal prognosis, partially due to our inability to completely remove and kill all GBM cells. Rapid tumor recurrence contributes to a median survival of only 15 months with the current standard of care which includes maximal surgical resec...

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Bibliographic Details
Main Authors: Cyntanna C. Hawkins, Tomader Ali, Sasanka Ramanadham, Anita B. Hjelmeland
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Biomolecules
Subjects:
glioblastoma
sphingolipid
sphingosine-1-phosphate
sphingomyelinase
sphingomyelin
metastasis
Online Access:https://www.mdpi.com/2218-273X/10/10/1357

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