Paparan Debu Batubara Subkronik pada Peroksidasi Lipid dan Kadar Gula Darah Tikus Diabetes Melitus
In South Kalimantan, prevalence of diabetes mellitus was 11.1%. South Kalimantan is a province with coal mine spread in all districts. This condition induce coal dust exposure on diabetes mellitus patients. Aim of this study was to measure lipid peroxidation by subchronic coal dust exposure and its...
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Universitas Padjajaran
2011-12-01
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doaj-3a6639f0beb94adea3ad3d896f15f7552020-11-24T23:37:14ZengUniversitas PadjajaranMajalah Kedokteran Bandung0126-074X2338-62232011-12-0143418919210.15395/mkb.v43n4.68Paparan Debu Batubara Subkronik pada Peroksidasi Lipid dan Kadar Gula Darah Tikus Diabetes MelitusAgus Yuwono0Bambang Setiawan1Nia Kania2M. Aris Widodo3Bagian Ilmu Penyakit DalamBagian Kimia KedokteranBagian Patologi Anatomi RSUD Ulin Banjarmasin, Fakultas Kedokteran Universitas Lambung Mangkurat Banjarbaru Bagian Farmakologi, Fakultas Kedokteran Universitas Brawijaya MalangIn South Kalimantan, prevalence of diabetes mellitus was 11.1%. South Kalimantan is a province with coal mine spread in all districts. This condition induce coal dust exposure on diabetes mellitus patients. Aim of this study was to measure lipid peroxidation by subchronic coal dust exposure and its effect on glucose level in Wistar rats model of diabetes mellitus. Group included diabetes mellitus Wistar rats (P1), diabetes mellitus + coal dust exposure at dose 12.5 mg/m3 1 hour/day for 28 days (P2) and diabetes mellitus + coal dust exposure at dose 25 mg/m3 1 hour/day for 28 days (P3) on 6 rats, respectively. This research was done from August–October 2010. Analysis of variance (ANOVA) test concluded no significant differently on increased plasma malondialdehyde (MDA) level between all groups (p>0.05). Percentage of blood glucose level decreased 23.6%, 16.9% and 9.3% for P1, P2, P3 group, respectively. Unpaired t test concluded that blood glucose level were not significant differently between pre and post treatment in all groups (p>0.05). There was no correlation between plasma MDA level and blood glucose level in all groups of exposure (p>0.05). In conclusions, that subchronic coal dust exposure doesn’t increase lipid peroxidation and no effect on blood glucose level in diabetes mellitus rats and no correlation between MDA dan blood glucose level.http://journal.fk.unpad.ac.id/index.php/mkb/article/view/68Coal dustdiabetes mellitushyperglycemialipid peroxidation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Agus Yuwono Bambang Setiawan Nia Kania M. Aris Widodo |
spellingShingle |
Agus Yuwono Bambang Setiawan Nia Kania M. Aris Widodo Paparan Debu Batubara Subkronik pada Peroksidasi Lipid dan Kadar Gula Darah Tikus Diabetes Melitus Majalah Kedokteran Bandung Coal dust diabetes mellitus hyperglycemia lipid peroxidation |
author_facet |
Agus Yuwono Bambang Setiawan Nia Kania M. Aris Widodo |
author_sort |
Agus Yuwono |
title |
Paparan Debu Batubara Subkronik pada Peroksidasi Lipid dan Kadar Gula Darah Tikus Diabetes Melitus |
title_short |
Paparan Debu Batubara Subkronik pada Peroksidasi Lipid dan Kadar Gula Darah Tikus Diabetes Melitus |
title_full |
Paparan Debu Batubara Subkronik pada Peroksidasi Lipid dan Kadar Gula Darah Tikus Diabetes Melitus |
title_fullStr |
Paparan Debu Batubara Subkronik pada Peroksidasi Lipid dan Kadar Gula Darah Tikus Diabetes Melitus |
title_full_unstemmed |
Paparan Debu Batubara Subkronik pada Peroksidasi Lipid dan Kadar Gula Darah Tikus Diabetes Melitus |
title_sort |
paparan debu batubara subkronik pada peroksidasi lipid dan kadar gula darah tikus diabetes melitus |
publisher |
Universitas Padjajaran |
series |
Majalah Kedokteran Bandung |
issn |
0126-074X 2338-6223 |
publishDate |
2011-12-01 |
description |
In South Kalimantan, prevalence of diabetes mellitus was 11.1%. South Kalimantan is a province with coal mine spread in all districts. This condition induce coal dust exposure on diabetes mellitus patients. Aim of this study was to measure lipid peroxidation by subchronic coal dust exposure and its effect on glucose level in Wistar rats model of diabetes mellitus. Group included diabetes mellitus Wistar rats (P1), diabetes mellitus + coal dust exposure at dose 12.5 mg/m3 1 hour/day for 28 days (P2) and diabetes mellitus + coal dust exposure at dose 25 mg/m3 1 hour/day for 28 days (P3) on 6 rats, respectively. This research was done from August–October 2010. Analysis of variance (ANOVA) test concluded no significant differently on increased plasma malondialdehyde (MDA) level between all groups (p>0.05). Percentage of blood glucose level decreased 23.6%, 16.9% and 9.3% for P1, P2, P3 group, respectively. Unpaired t test concluded that blood glucose level were not significant differently between pre and post treatment in all groups (p>0.05). There was no correlation between plasma MDA level and blood glucose level in all groups of exposure (p>0.05). In conclusions, that subchronic coal dust exposure doesn’t increase lipid peroxidation and no effect on blood glucose level in diabetes mellitus rats and no correlation between MDA dan blood glucose level. |
topic |
Coal dust diabetes mellitus hyperglycemia lipid peroxidation |
url |
http://journal.fk.unpad.ac.id/index.php/mkb/article/view/68 |
work_keys_str_mv |
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