The electronic nose: emerging biomarkers in lung cancer diagnostics
Lung cancer is very common and the most common cause of cancer death worldwide. Despite recent progress in the systemic treatment of lung cancer (checkpoint inhibitors and tyrosine kinase inhibitors), each year, >1.5 million people die due to this disease. Most lung cancer patients already have a...
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2019-12-01
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doaj-3a70ff6772984854a0bc3c284d3c00be2020-12-21T10:22:42ZengEuropean Respiratory SocietyBreathe1810-68382073-47352019-12-01154e135e14110.1183/20734735.0309-20190309-2019The electronic nose: emerging biomarkers in lung cancer diagnosticsWouter H. van Geffen0Kevin Lamote1Adrien Costantini2Lizza E.L. Hendriks3Najib M. Rahman4Torsten G. Blum5Jan van Meerbeeck6 Dept of Pulmonary Medicine, Medical Centre Leeuwarden, Leeuwarden, The Netherlands Dept of Pulmonology, Antwerp University Hospital, Edegem, Belgium Dept of Respiratory Diseases and Thoracic Oncology, APHP, Hôpital Ambroise Paré, Boulogne-Billancourt, France Dept of Pulmonary Medicine, GROW – School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands Oxford Respiratory Trials Unit, Nuffield Dept of Medicine, University of Oxford, Oxford, UK Lungenklinik Heckeshorn, Helios Klinikum Emil von Behring, Berlin, Germany Dept of Pulmonology, Antwerp University Hospital, Edegem, Belgium Lung cancer is very common and the most common cause of cancer death worldwide. Despite recent progress in the systemic treatment of lung cancer (checkpoint inhibitors and tyrosine kinase inhibitors), each year, >1.5 million people die due to this disease. Most lung cancer patients already have advanced disease at the time of diagnosis. Computed tomography screening of high-risk individuals can detect lung cancer at an earlier stage but at a cost of false-positive findings. Biomarkers could lead towards a reduction of these false-positive findings and earlier lung cancer diagnosis, and have the potential to improve outcomes and treatment monitoring. To date, there is a lack of such biomarkers for lung cancer and other thoracic malignancies, although electronic nose (e-nose)-derived biomarkers are of interest. E-nose techniques using exhaled breath component measurements can detect lung cancer with a sensitivity ranging from 71% to 96% and specificity from 33 to 100%. In some case series, such results have been validated but this is mostly using internal validation and hence, more work is needed. Furthermore, standardised sampling and analysis methods are lacking, impeding interstudy comparison and clinical implementation. In this narrative review, we provide an overview of the currently available data on E-nose technology for lung cancer detection.http://breathe.ersjournals.com/content/15/4/e135.full |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wouter H. van Geffen Kevin Lamote Adrien Costantini Lizza E.L. Hendriks Najib M. Rahman Torsten G. Blum Jan van Meerbeeck |
spellingShingle |
Wouter H. van Geffen Kevin Lamote Adrien Costantini Lizza E.L. Hendriks Najib M. Rahman Torsten G. Blum Jan van Meerbeeck The electronic nose: emerging biomarkers in lung cancer diagnostics Breathe |
author_facet |
Wouter H. van Geffen Kevin Lamote Adrien Costantini Lizza E.L. Hendriks Najib M. Rahman Torsten G. Blum Jan van Meerbeeck |
author_sort |
Wouter H. van Geffen |
title |
The electronic nose: emerging biomarkers in lung cancer diagnostics |
title_short |
The electronic nose: emerging biomarkers in lung cancer diagnostics |
title_full |
The electronic nose: emerging biomarkers in lung cancer diagnostics |
title_fullStr |
The electronic nose: emerging biomarkers in lung cancer diagnostics |
title_full_unstemmed |
The electronic nose: emerging biomarkers in lung cancer diagnostics |
title_sort |
electronic nose: emerging biomarkers in lung cancer diagnostics |
publisher |
European Respiratory Society |
series |
Breathe |
issn |
1810-6838 2073-4735 |
publishDate |
2019-12-01 |
description |
Lung cancer is very common and the most common cause of cancer death worldwide. Despite recent progress in the systemic treatment of lung cancer (checkpoint inhibitors and tyrosine kinase inhibitors), each year, >1.5 million people die due to this disease. Most lung cancer patients already have advanced disease at the time of diagnosis. Computed tomography screening of high-risk individuals can detect lung cancer at an earlier stage but at a cost of false-positive findings. Biomarkers could lead towards a reduction of these false-positive findings and earlier lung cancer diagnosis, and have the potential to improve outcomes and treatment monitoring. To date, there is a lack of such biomarkers for lung cancer and other thoracic malignancies, although electronic nose (e-nose)-derived biomarkers are of interest. E-nose techniques using exhaled breath component measurements can detect lung cancer with a sensitivity ranging from 71% to 96% and specificity from 33 to 100%. In some case series, such results have been validated but this is mostly using internal validation and hence, more work is needed. Furthermore, standardised sampling and analysis methods are lacking, impeding interstudy comparison and clinical implementation. In this narrative review, we provide an overview of the currently available data on E-nose technology for lung cancer detection. |
url |
http://breathe.ersjournals.com/content/15/4/e135.full |
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