Challenges of Neoantigen Targeting in Lynch Syndrome and Constitutional Mismatch Repair Deficiency Syndrome

Challenges of Neoantigen Targeting in Lynch Syndrome and Constitutional Mismatch Repair Deficiency Syndrome

Lynch syndrome (LS) and constitutional mismatch repair deficiency (CMMRD) are hereditary disorders characterised by a highly increased risk of cancer development. This is due to germline aberrations in the mismatch repair (MMR) genes, which results in a high mutational load in tumours of these patie...

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Bibliographic Details
Main Authors: Asima Abidi, Mark A. J. Gorris, Evan Brennan, Marjolijn C. J. Jongmans, Dilys D. Weijers, Roland P. Kuiper, Richarda M. de Voer, Nicoline Hoogerbrugge, Gerty Schreibelt, I. Jolanda M. de Vries
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
Lynch Syndrome
hereditary cancer
CMMRD
neoantigen
colorectal cancer
mismatch repair deficiency
Online Access:https://www.mdpi.com/2072-6694/13/10/2345

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