Distinguishing type 2 diabetes from type 1 diabetes in African American and Hispanic American pediatric patients.
To test the hypothesis that clinical observations made at patient presentation can distinguish type 2 diabetes (T2D) from type 1 diabetes (T1D) in pediatric patients aged 2 to 18.Medical records of 227 African American and 112 Hispanic American pediatric patients diagnosed as T1D or T2D were examine...
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2012-01-01
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doaj-3a87f9911b5c4172b6ea71452f7b6d112020-11-24T20:49:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0173e3277310.1371/journal.pone.0032773Distinguishing type 2 diabetes from type 1 diabetes in African American and Hispanic American pediatric patients.Nancy KellerSuruchi BhatiaJeanah N BradenGinny GildengorinJameel JohnsonRachel YedlinTeresa TsengJacquelyn KnappNicole GlaserPaula JossanShawn TeranErinn T RhodesJanelle A NobleTo test the hypothesis that clinical observations made at patient presentation can distinguish type 2 diabetes (T2D) from type 1 diabetes (T1D) in pediatric patients aged 2 to 18.Medical records of 227 African American and 112 Hispanic American pediatric patients diagnosed as T1D or T2D were examined to compare parameters in the two diseases. Age at presentation, BMI z-score, and gender were the variables used in logistic regression analysis to create models for T2D prediction.The regression-based model created from African American data had a sensitivity of 92% and a specificity of 89%; testing of a replication cohort showed 91% sensitivity and 93% specificity. A model based on the Hispanic American data showed 92% sensitivity and 90% specificity. Similarities between African American and Hispanic American patients include: (1) age at onset for both T1D and T2D decreased from the 1980s to the 2000s; (2) risk of T2D increased markedly with obesity. Racial/ethnic-specific observations included: (1) in African American patients, the proportion of females was significantly higher than that of males for T2D compared to T1D (p<0.0001); (2) in Hispanic Americans, the level of glycated hemoglobin (HbA1c) was significantly higher in T1D than in T2D (p<0.002) at presentation; (3) the strongest contributor to T2D risk was female gender in African Americans, while the strongest contributor to T2D risk was BMI z-score in Hispanic Americans.Distinction of T2D from T1D at patient presentation was possible with good sensitivity and specificity using only three easily-assessed variables: age, gender, and BMI z-score. In African American pediatric diabetes patients, gender was the strongest predictor of T2D, while in Hispanic patients, BMI z-score was the strongest predictor. This suggests that race/ethnic specific models may be useful to optimize distinction of T1D from T2D at presentation.http://europepmc.org/articles/PMC3296728?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nancy Keller Suruchi Bhatia Jeanah N Braden Ginny Gildengorin Jameel Johnson Rachel Yedlin Teresa Tseng Jacquelyn Knapp Nicole Glaser Paula Jossan Shawn Teran Erinn T Rhodes Janelle A Noble |
spellingShingle |
Nancy Keller Suruchi Bhatia Jeanah N Braden Ginny Gildengorin Jameel Johnson Rachel Yedlin Teresa Tseng Jacquelyn Knapp Nicole Glaser Paula Jossan Shawn Teran Erinn T Rhodes Janelle A Noble Distinguishing type 2 diabetes from type 1 diabetes in African American and Hispanic American pediatric patients. PLoS ONE |
author_facet |
Nancy Keller Suruchi Bhatia Jeanah N Braden Ginny Gildengorin Jameel Johnson Rachel Yedlin Teresa Tseng Jacquelyn Knapp Nicole Glaser Paula Jossan Shawn Teran Erinn T Rhodes Janelle A Noble |
author_sort |
Nancy Keller |
title |
Distinguishing type 2 diabetes from type 1 diabetes in African American and Hispanic American pediatric patients. |
title_short |
Distinguishing type 2 diabetes from type 1 diabetes in African American and Hispanic American pediatric patients. |
title_full |
Distinguishing type 2 diabetes from type 1 diabetes in African American and Hispanic American pediatric patients. |
title_fullStr |
Distinguishing type 2 diabetes from type 1 diabetes in African American and Hispanic American pediatric patients. |
title_full_unstemmed |
Distinguishing type 2 diabetes from type 1 diabetes in African American and Hispanic American pediatric patients. |
title_sort |
distinguishing type 2 diabetes from type 1 diabetes in african american and hispanic american pediatric patients. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
To test the hypothesis that clinical observations made at patient presentation can distinguish type 2 diabetes (T2D) from type 1 diabetes (T1D) in pediatric patients aged 2 to 18.Medical records of 227 African American and 112 Hispanic American pediatric patients diagnosed as T1D or T2D were examined to compare parameters in the two diseases. Age at presentation, BMI z-score, and gender were the variables used in logistic regression analysis to create models for T2D prediction.The regression-based model created from African American data had a sensitivity of 92% and a specificity of 89%; testing of a replication cohort showed 91% sensitivity and 93% specificity. A model based on the Hispanic American data showed 92% sensitivity and 90% specificity. Similarities between African American and Hispanic American patients include: (1) age at onset for both T1D and T2D decreased from the 1980s to the 2000s; (2) risk of T2D increased markedly with obesity. Racial/ethnic-specific observations included: (1) in African American patients, the proportion of females was significantly higher than that of males for T2D compared to T1D (p<0.0001); (2) in Hispanic Americans, the level of glycated hemoglobin (HbA1c) was significantly higher in T1D than in T2D (p<0.002) at presentation; (3) the strongest contributor to T2D risk was female gender in African Americans, while the strongest contributor to T2D risk was BMI z-score in Hispanic Americans.Distinction of T2D from T1D at patient presentation was possible with good sensitivity and specificity using only three easily-assessed variables: age, gender, and BMI z-score. In African American pediatric diabetes patients, gender was the strongest predictor of T2D, while in Hispanic patients, BMI z-score was the strongest predictor. This suggests that race/ethnic specific models may be useful to optimize distinction of T1D from T2D at presentation. |
url |
http://europepmc.org/articles/PMC3296728?pdf=render |
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