Clinical applications of immunoglobulin in neuromuscular diseases: focus on inflammatory myopathies

• Main Authors: Paulo Victor Sgobbi de Souza, Wladimir Bocca Vieira de Rezende Pinto, Acary Souza Bulle Oliveira
• Format: Article
• Language: English
• Published: Academia Brasileira de Neurologia (ABNEURO) 2014-12-01
• Series: Arquivos de Neuro-Psiquiatria
• Subjects: imunoglobulina; doenças neuromusculares; autoimunidade; miopatia inflamatória
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2014001200966&lng=en&tlng=en

During recent years, an increasing number of neuromuscular diseases have been recognized either to be caused primarily by autoimmune mechanisms, or to have important autoimmune components. The involved pathophysiological mechanisms and clinical manifestations have been better recognized and many of these disorders are potentially treatable by immunosuppression or by immunomodulation with intravenous immunoglobulin (IVIg). IVIg has been tried in a variety of immune-mediated neurological diseases, being target of widespread use in central and peripheral nervous systems diseases. Objective To give an overview of the main topics regarding the mechanism of action and different therapeutic uses of IVIg in neurological practice, mainly in neuromuscular diseases.