Impact of chronic obstructive pulmonary disease on patient with acute myocardial infarction undergoing primary percutaneous coronary intervention

• Main Authors: Pei-Hsun Sung, Sheng-Ying Chung, Cheuk-Kwan Sun, Cheng-Hsu Yang, Shyh-Ming Chen, Chi-Ling Hang, Chien-Jen Chen, Kuo-Ho Yeh, Yung-Lung Chen, Chiung-Jen Wu, Hsuen-wen Chang, Tzu-Hsien Tsai, Hon-Kan Yip
• Format: Article
• Language: English
• Published: Elsevier 2013-12-01
• Series: Biomedical Journal
• Subjects: Acute myocardial infarction; chronic obstructive lung disease; clinical outcome
• Online Access: http://www.biomedj.org/article.asp?issn=2319-4170;year=2013;volume=36;issue=6;spage=274;epage=281;aulast=Sung

Background: This study reported the incidence and prognostic outcome of chronic obstructive lung disease (COPD) patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Methods: Between January 2002 and May 2011, totally 1554 consecutive patients who experienced STEMI undergoing primary PCI were enrolled into the study. Results: Of the 1554 patients, 124 (9.7%) with diagnosis of COPD and 1430 (90.3%) without COPD were categorized into group 1 and group 2. Although no difference in in-hospital mortality was noted between the two groups (p = 0.726). However, the hospitalization duration was notably longer (p = 0.003), the incidences of recurrent MI and re-hospitalization for congestive heart failure were significantly higher in group 1 than in group 2 (all p < 0.02). Although Kaplan-Meier analysis demonstrated that the incidence of freedom from one-year major adverse clinical outcome (MACO) (defined as recurrent MI, re-admission for congestive heart failure was significantly lower in group 1 than group 2 (p = 0.012), multivariate Cox regression analysis showed COPD was not an independent predictor of MACO-free time after adjusting traditional risk factors. Conclusion: COPD was not an independent predictor of short-term and medium-term MACO in patients with STEMI undergoing primary PCI.