Human papillomavirus and Epstein-Barr virus infections in breast cancer from chile

• Main Authors: Eizuru Yoshito, Solís Luisa, Padilla Oslando, Ampuero Sandra, González Carolina, Koriyama Chihaya, Khan Noureen, Aguayo Francisco, Corvalán Alejandro, Akiba Suminori
• Format: Article
• Language: English
• Published: BMC 2011-06-01
• Series: Infectious Agents and Cancer
• Subjects: papillomavirus; breast; cancer; HPV; integration
• Online Access: http://www.infectagentscancer.com/content/6/1/7

<p>Abstract</p> <p>Background</p> <p>Human papillomavirus (HPV) and Epstein Barr virus (EBV) have been found in breast carcinomas (BCs) around the world. In this study, fifty-five BCs from Chile were analyzed for HPV and EBV presence. In addition, HPV-16 viral load/physical status and E6/E7 expressions were determined.</p> <p>Results</p> <p>The amplification of a housekeeping gene showed that 46/55 samples (84%) had amplifiable DNA. HPV-16 was detected in 4/46 BCs (8.7%) and EBV was detected in 3/46 (6.5%) BCs. The analysis of HPV-16 physical status showed that this virus was integrated in all of the tumors with a relatively low viral load (range: 0.14 to 33.8 copies/cell). E6 and E7 transcripts, however, were not detected in any HPV-16 positive specimens. Using a Cox-regression model, we found a statistically significant association between EBV presence and poor survival (p = 0.013).</p> <p>Conclusions</p> <p>The findings in this study suggest that it is unlikely that HPV and/or EBV play a direct role in the etiology of BC.</p>