Clinical Characteristics and Efficacy of Iron Treatment for Restless Legs Syndrome Patients with Very Low Ferritin Levels
Restless legs syndrome (RLS) is associated with dopaminergic dysfunction, and iron deficiency, manifesting as low ferritin. However, ferritin levels do not correlate well with demographic data. Based on the hypothesis that very low ferritin can accurately reflect clinical information, we herein desc...
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doaj-3aa19f86d164454d88b7f46326a6b8312020-11-24T21:10:27ZengKorean Society of Sleep MedicineSleep Medicine Research2093-91752233-88532018-12-019211812310.17241/smr.2018.00171124Clinical Characteristics and Efficacy of Iron Treatment for Restless Legs Syndrome Patients with Very Low Ferritin LevelsTae-Joon Kim0Jin-Sun Jun1Keun Tae Kim2Tae-Won Yang3Byeong-Su Park4Jung-Ah Lim5Jung-Ick Byun6Jun-Sang Sunwoo7Jung-Won Shin8Ki-Young Jung9 Department of Neurology, Seoul National University Hospital, Seoul, Korea Department of Neurology, Seoul National University Hospital, Seoul, Korea Department of Neurology, Keimyung University Dongsan Medical Center, Daegu, Korea Department of Neurology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Korea Department of Neurology, Ulsan University Hospital, Ulsan, Korea Department of Neurology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea Department of Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea Department of Neurology, Soonchunhyang University School of Medicine, Seoul, Korea Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, Korea Department of Neurology, Seoul National University Hospital, Seoul, KoreaRestless legs syndrome (RLS) is associated with dopaminergic dysfunction, and iron deficiency, manifesting as low ferritin. However, ferritin levels do not correlate well with demographic data. Based on the hypothesis that very low ferritin can accurately reflect clinical information, we herein described characteristics and treatment efficacy of RLS patients with ferritin levels under 15 ng/mL. We retrospectively reviewed 196 patients and collected clinical data. Twenty-one patients had ferritin levels under 15 ng/mL and were compared with those having ferritin levels over 15 ng/mL. The patients with very low ferritin levels were predominantly female, had earlier onset of symptoms, and showed a superior response to iron therapy. In conclusion, RLS patients with ferritin levels under 15 ng/mL showed distinct demographic features and treatment efficacy. Further studies on more patients with long-term follow-up are warranted to support this observation.http://www.sleepmedres.org/upload/pdf/smr-2018-00171.pdfRestless legs syndromeFerritinIron |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tae-Joon Kim Jin-Sun Jun Keun Tae Kim Tae-Won Yang Byeong-Su Park Jung-Ah Lim Jung-Ick Byun Jun-Sang Sunwoo Jung-Won Shin Ki-Young Jung |
spellingShingle |
Tae-Joon Kim Jin-Sun Jun Keun Tae Kim Tae-Won Yang Byeong-Su Park Jung-Ah Lim Jung-Ick Byun Jun-Sang Sunwoo Jung-Won Shin Ki-Young Jung Clinical Characteristics and Efficacy of Iron Treatment for Restless Legs Syndrome Patients with Very Low Ferritin Levels Sleep Medicine Research Restless legs syndrome Ferritin Iron |
author_facet |
Tae-Joon Kim Jin-Sun Jun Keun Tae Kim Tae-Won Yang Byeong-Su Park Jung-Ah Lim Jung-Ick Byun Jun-Sang Sunwoo Jung-Won Shin Ki-Young Jung |
author_sort |
Tae-Joon Kim |
title |
Clinical Characteristics and Efficacy of Iron Treatment for Restless Legs Syndrome Patients with Very Low Ferritin Levels |
title_short |
Clinical Characteristics and Efficacy of Iron Treatment for Restless Legs Syndrome Patients with Very Low Ferritin Levels |
title_full |
Clinical Characteristics and Efficacy of Iron Treatment for Restless Legs Syndrome Patients with Very Low Ferritin Levels |
title_fullStr |
Clinical Characteristics and Efficacy of Iron Treatment for Restless Legs Syndrome Patients with Very Low Ferritin Levels |
title_full_unstemmed |
Clinical Characteristics and Efficacy of Iron Treatment for Restless Legs Syndrome Patients with Very Low Ferritin Levels |
title_sort |
clinical characteristics and efficacy of iron treatment for restless legs syndrome patients with very low ferritin levels |
publisher |
Korean Society of Sleep Medicine |
series |
Sleep Medicine Research |
issn |
2093-9175 2233-8853 |
publishDate |
2018-12-01 |
description |
Restless legs syndrome (RLS) is associated with dopaminergic dysfunction, and iron deficiency, manifesting as low ferritin. However, ferritin levels do not correlate well with demographic data. Based on the hypothesis that very low ferritin can accurately reflect clinical information, we herein described characteristics and treatment efficacy of RLS patients with ferritin levels under 15 ng/mL. We retrospectively reviewed 196 patients and collected clinical data. Twenty-one patients had ferritin levels under 15 ng/mL and were compared with those having ferritin levels over 15 ng/mL. The patients with very low ferritin levels were predominantly female, had earlier onset of symptoms, and showed a superior response to iron therapy. In conclusion, RLS patients with ferritin levels under 15 ng/mL showed distinct demographic features and treatment efficacy. Further studies on more patients with long-term follow-up are warranted to support this observation. |
topic |
Restless legs syndrome Ferritin Iron |
url |
http://www.sleepmedres.org/upload/pdf/smr-2018-00171.pdf |
work_keys_str_mv |
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