Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study.
Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional cure for HIV-infected patients appears to be a more reachable short-term goal. We identified 14 HIV patients (post-treat...
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doaj-3aa2706450d844e9b1b3dc6d988e94f32020-11-25T00:12:31ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742013-03-0193e100321110.1371/journal.ppat.1003211Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study.Asier Sáez-CiriónCharline BacchusLaurent HocquelouxVéronique Avettand-FenoelIsabelle GiraultCamille LecurouxValerie PotardPierre VersmisseAdeline MelardThierry PrazuckBenjamin DescoursJulien GuergnonJean-Paul ViardFaroudy BoufassaOlivier LambotteCécile GoujardLaurence MeyerDominique CostagliolaAlain VenetGianfranco PancinoBrigitte AutranChristine RouziouxANRS VISCONTI Study GroupCombination antiretroviral therapy (cART) reduces HIV-associated morbidities and mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional cure for HIV-infected patients appears to be a more reachable short-term goal. We identified 14 HIV patients (post-treatment controllers [PTCs]) whose viremia remained controlled for several years after the interruption of prolonged cART initiated during the primary infection. Most PTCs lacked the protective HLA B alleles that are overrepresented in spontaneous HIV controllers (HICs); instead, they carried risk-associated HLA alleles that were largely absent among the HICs. Accordingly, the PTCs had poorer CD8+ T cell responses and more severe primary infections than the HICs did. Moreover, the incidence of viral control after the interruption of early antiretroviral therapy was higher among the PTCs than has been reported for spontaneous control. Off therapy, the PTCs were able to maintain and, in some cases, further reduce an extremely low viral reservoir. We found that long-lived HIV-infected CD4+ T cells contributed poorly to the total resting HIV reservoir in the PTCs because of a low rate of infection of naïve T cells and a skewed distribution of resting memory CD4+ T cell subsets. Our results show that early and prolonged cART may allow some individuals with a rather unfavorable background to achieve long-term infection control and may have important implications in the search for a functional HIV cure.http://europepmc.org/articles/PMC3597518?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Asier Sáez-Cirión Charline Bacchus Laurent Hocqueloux Véronique Avettand-Fenoel Isabelle Girault Camille Lecuroux Valerie Potard Pierre Versmisse Adeline Melard Thierry Prazuck Benjamin Descours Julien Guergnon Jean-Paul Viard Faroudy Boufassa Olivier Lambotte Cécile Goujard Laurence Meyer Dominique Costagliola Alain Venet Gianfranco Pancino Brigitte Autran Christine Rouzioux ANRS VISCONTI Study Group |
spellingShingle |
Asier Sáez-Cirión Charline Bacchus Laurent Hocqueloux Véronique Avettand-Fenoel Isabelle Girault Camille Lecuroux Valerie Potard Pierre Versmisse Adeline Melard Thierry Prazuck Benjamin Descours Julien Guergnon Jean-Paul Viard Faroudy Boufassa Olivier Lambotte Cécile Goujard Laurence Meyer Dominique Costagliola Alain Venet Gianfranco Pancino Brigitte Autran Christine Rouzioux ANRS VISCONTI Study Group Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. PLoS Pathogens |
author_facet |
Asier Sáez-Cirión Charline Bacchus Laurent Hocqueloux Véronique Avettand-Fenoel Isabelle Girault Camille Lecuroux Valerie Potard Pierre Versmisse Adeline Melard Thierry Prazuck Benjamin Descours Julien Guergnon Jean-Paul Viard Faroudy Boufassa Olivier Lambotte Cécile Goujard Laurence Meyer Dominique Costagliola Alain Venet Gianfranco Pancino Brigitte Autran Christine Rouzioux ANRS VISCONTI Study Group |
author_sort |
Asier Sáez-Cirión |
title |
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. |
title_short |
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. |
title_full |
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. |
title_fullStr |
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. |
title_full_unstemmed |
Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study. |
title_sort |
post-treatment hiv-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy anrs visconti study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Pathogens |
issn |
1553-7366 1553-7374 |
publishDate |
2013-03-01 |
description |
Combination antiretroviral therapy (cART) reduces HIV-associated morbidities and mortalities but cannot cure the infection. Given the difficulty of eradicating HIV-1, a functional cure for HIV-infected patients appears to be a more reachable short-term goal. We identified 14 HIV patients (post-treatment controllers [PTCs]) whose viremia remained controlled for several years after the interruption of prolonged cART initiated during the primary infection. Most PTCs lacked the protective HLA B alleles that are overrepresented in spontaneous HIV controllers (HICs); instead, they carried risk-associated HLA alleles that were largely absent among the HICs. Accordingly, the PTCs had poorer CD8+ T cell responses and more severe primary infections than the HICs did. Moreover, the incidence of viral control after the interruption of early antiretroviral therapy was higher among the PTCs than has been reported for spontaneous control. Off therapy, the PTCs were able to maintain and, in some cases, further reduce an extremely low viral reservoir. We found that long-lived HIV-infected CD4+ T cells contributed poorly to the total resting HIV reservoir in the PTCs because of a low rate of infection of naïve T cells and a skewed distribution of resting memory CD4+ T cell subsets. Our results show that early and prolonged cART may allow some individuals with a rather unfavorable background to achieve long-term infection control and may have important implications in the search for a functional HIV cure. |
url |
http://europepmc.org/articles/PMC3597518?pdf=render |
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