Fenofibrate Reduces the Severity of Neuroretinopathy in a Type 2 Model of Diabetes without Inducing Peroxisome Proliferator-Activated Receptor Alpha-Dependent Retinal Gene Expression

Fenofibrate Reduces the Severity of Neuroretinopathy in a Type 2 Model of Diabetes without Inducing Peroxisome Proliferator-Activated Receptor Alpha-Dependent Retinal Gene Expression

Fenofibrate slows the progression of clinical diabetic retinopathy (DR), but its mechanism of action in the retina remains unclear. Fenofibrate is a known agonist of peroxisome proliferator-activated receptor alpha (PPARα), a transcription factor critical for regulating metabolism, inflammation and...

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Bibliographic Details
Main Authors: Jennifer M. Enright, Sheng Zhang, Christina Thebeau, Emily Siebert, Alexander Jin, Veda Gadiraju, Xiaodong Zhang, Shiming Chen, Clay F. Semenkovich, Rithwick Rajagopal
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Journal of Clinical Medicine
Subjects:
fenofibrate
diabetic retinopathy
PPAR-alpha
electroretinography
Müller glia
Online Access:https://www.mdpi.com/2077-0383/10/1/126

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