Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells
Purpose: The plasma membrane localization and transport activity of multidrug resistance-associated protein 2 (MRP2/ABCC2) and P-glycoprotein (P-gp/ABCB1) efflux transporters are governed by transporter-associated proteins. Phosphatidylinositol 4,5-bisphosphate (PIP2) formed by phosphatidylinositol...
Main Authors: | Atsushi Kawase, Yuta Inoue, Miho Hirosoko, Yuka Sugihara, Hiroaki Shimada, Masahiro Iwaki |
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Format: | Article |
Language: | English |
Published: |
Canadian Society for Pharmaceutical Sciences
2019-11-01
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Series: | Journal of Pharmacy & Pharmaceutical Sciences |
Online Access: | https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/30444 |
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