Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients

Stem cell-derived motor neurons from spinal and bulbar muscular atrophy patients

Spinal and bulbar muscular atrophy (SBMA, Kennedy's disease) is a motor neuron disease caused by polyglutamine repeat expansion in the androgen receptor. Although degeneration occurs in the spinal cord and muscle, the exact mechanism is not clear. Induced pluripotent stem cells from spinal and...

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Bibliographic Details
Main Authors:	Christopher Grunseich, Kristen Zukosky, Ilona R. Kats, Laboni Ghosh, George G. Harmison, Laura C. Bott, Carlo Rinaldi, Ke-lian Chen, Guibin Chen, Manfred Boehm, Kenneth H. Fischbeck
Format:	Article
Language:	English
Published:	Elsevier 2014-10-01
Series:	Neurobiology of Disease
Subjects:	Spinal and bulbar muscular atrophy Induced pluripotent stem cells Motor neuron disease Androgen receptor
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996114001648

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