Serum contents of endocannabinoids are correlated with blood pressure in depressed women
<p>Abstract</p> <p>Background</p> <p>Depression is known to be a risk factor for cardiovascular diseases but the underlying mechanisms remain unclear. Since recent preclinical evidence suggests that endogenous agonists of cannabinoid receptors (endocannabinoids) are inv...
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doaj-3ab065ade238498cbf336dfbb503833b2020-11-25T00:03:09ZengBMCLipids in Health and Disease1476-511X2012-02-011113210.1186/1476-511X-11-32Serum contents of endocannabinoids are correlated with blood pressure in depressed womenHo WS VanessaHill Matthew NMiller Gregory EGorzalka Boris BHillard Cecilia J<p>Abstract</p> <p>Background</p> <p>Depression is known to be a risk factor for cardiovascular diseases but the underlying mechanisms remain unclear. Since recent preclinical evidence suggests that endogenous agonists of cannabinoid receptors (endocannabinoids) are involved in both cardiovascular function and depression, we asked whether endocannabinoids correlated with either in humans.</p> <p>Results</p> <p>Resting blood pressure and serum content of endocannabinoids in ambulatory, medication-free, female volunteers with depression (n = 28) and their age- and ethnicity-matched controls (n = 27) were measured. In females with depression, both diastolic and mean arterial blood pressures were positively correlated with serum contents of the endocannabinoids, <it>N</it>-arachidonylethanolamine (anandamide) and 2-arachidonoylglycerol. There was no correlation between blood pressure and endocannabinoids in control subjects. Furthermore, depressed women had significantly higher systolic blood pressure than control subjects. A larger body mass index was also found in depressed women, however, it was not significantly correlated with serum endocannabinoid contents.</p> <p>Conclusions</p> <p>This preliminary study raises the possibility that endocannabinoids play a role in blood pressure regulation in depressives with higher blood pressure, and suggests an interrelationship among endocannabinoids, depression and cardiovascular risk factors in women.</p> http://www.lipidworld.com/content/11/1/32DepressionSystolic blood pressureDiastolic blood pressureCardiovascular riskAnandamide2-arachidonoylglycerol |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ho WS Vanessa Hill Matthew N Miller Gregory E Gorzalka Boris B Hillard Cecilia J |
spellingShingle |
Ho WS Vanessa Hill Matthew N Miller Gregory E Gorzalka Boris B Hillard Cecilia J Serum contents of endocannabinoids are correlated with blood pressure in depressed women Lipids in Health and Disease Depression Systolic blood pressure Diastolic blood pressure Cardiovascular risk Anandamide 2-arachidonoylglycerol |
author_facet |
Ho WS Vanessa Hill Matthew N Miller Gregory E Gorzalka Boris B Hillard Cecilia J |
author_sort |
Ho WS Vanessa |
title |
Serum contents of endocannabinoids are correlated with blood pressure in depressed women |
title_short |
Serum contents of endocannabinoids are correlated with blood pressure in depressed women |
title_full |
Serum contents of endocannabinoids are correlated with blood pressure in depressed women |
title_fullStr |
Serum contents of endocannabinoids are correlated with blood pressure in depressed women |
title_full_unstemmed |
Serum contents of endocannabinoids are correlated with blood pressure in depressed women |
title_sort |
serum contents of endocannabinoids are correlated with blood pressure in depressed women |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2012-02-01 |
description |
<p>Abstract</p> <p>Background</p> <p>Depression is known to be a risk factor for cardiovascular diseases but the underlying mechanisms remain unclear. Since recent preclinical evidence suggests that endogenous agonists of cannabinoid receptors (endocannabinoids) are involved in both cardiovascular function and depression, we asked whether endocannabinoids correlated with either in humans.</p> <p>Results</p> <p>Resting blood pressure and serum content of endocannabinoids in ambulatory, medication-free, female volunteers with depression (n = 28) and their age- and ethnicity-matched controls (n = 27) were measured. In females with depression, both diastolic and mean arterial blood pressures were positively correlated with serum contents of the endocannabinoids, <it>N</it>-arachidonylethanolamine (anandamide) and 2-arachidonoylglycerol. There was no correlation between blood pressure and endocannabinoids in control subjects. Furthermore, depressed women had significantly higher systolic blood pressure than control subjects. A larger body mass index was also found in depressed women, however, it was not significantly correlated with serum endocannabinoid contents.</p> <p>Conclusions</p> <p>This preliminary study raises the possibility that endocannabinoids play a role in blood pressure regulation in depressives with higher blood pressure, and suggests an interrelationship among endocannabinoids, depression and cardiovascular risk factors in women.</p> |
topic |
Depression Systolic blood pressure Diastolic blood pressure Cardiovascular risk Anandamide 2-arachidonoylglycerol |
url |
http://www.lipidworld.com/content/11/1/32 |
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