Sulfur containing activated hydantions. Synthesis and screening some novel benzylidenehydantoins amino acids derivatives

• Main Author: El-Sayed Ragab A.
• Format: Article
• Language: English
• Published: Serbian Chemical Society 2001-01-01
• Series: Journal of the Serbian Chemical Society
• Subjects: benzylidenehydantoins amino acids; dipeptide derivatives
• Online Access: http://www.doiserbia.nb.rs/img/doi/0352-5139/2001/0352-51390101017E.pdf
• ISSN: 0352-5139; 1820-7421

5-Benzylidenehydantoin reacts with chlorosulfonic acid to give the corresponding p-sulfonyl chloride 1. Condensation with nucleophiles gives amino acid derivatives 2-7. Coupling reactions of some amino acid derivatives (2-6) with amino acid methyl ester hydrochloride in THF-Et3N medium using the dicyclohexylcarbodiimide method (DCC) furnish the desired dipeptidemethyl esters 8-12. The spectral data of the synthesized compounds are briefly discussed.