Heteromeric Channels Formed From Alternating Kv7.4 and Kv7.5 α-Subunits Display Biophysical, Regulatory, and Pharmacological Characteristics of Smooth Muscle M-Currents

Heteromeric Channels Formed From Alternating Kv7.4 and Kv7.5 α-Subunits Display Biophysical, Regulatory, and Pharmacological Characteristics of Smooth Muscle M-Currents

Smooth muscle cells of the vasculature, viscera, and lungs generally express multiple α-subunits of the Kv7 voltage-gated potassium channel family, with increasing evidence that both Kv7.4 and Kv7.5 can conduct “M-currents” that are functionally important for the regulation of smooth muscle contract...

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Bibliographic Details
Main Authors: Lyubov I. Brueggemann, Leanne L. Cribbs, Kenneth L. Byron
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Physiology
Subjects:
smooth muscle
Kv7.4
Kv7.5
α-subunit stoichiometry
M-current
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00992/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00992/full

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