A Drosophila Reporter for the Translational Activation of ATF4 Marks Stressed Cells during Development.
Eukaryotic cells have evolved signaling pathways that help to restore cellular homeostasis in response to various physiological or pathological conditions. ATF4 is a transcription factor whose mRNA translation is stimulated in response to stress-activated eIF2alpha kinases. Established conditions th...
Main Authors: | Kwonyoon Kang, Hyung Don Ryoo, Jung-Eun Park, Jee-Hyun Yoon, Min-Ji Kang |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC4433282?pdf=render |
Similar Items
-
Drosophila XBP1 expression reporter marks cells under endoplasmic reticulum stress and with high protein secretory load.
by: Hyung Don Ryoo, et al.
Published: (2013-01-01) -
Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR
by: Deepika Vasudevan, et al.
Published: (2020-09-01) -
The GCN2-ATF4 Signaling Pathway Induces 4E-BP to Bias Translation and Boost Antimicrobial Peptide Synthesis in Response to Bacterial Infection
by: Deepika Vasudevan, et al.
Published: (2017-11-01) -
PERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress.
by: Lifen Wang, et al.
Published: (2015-05-01) -
ATF4-Induced Warburg Metabolism Drives Over-Proliferation in Drosophila
by: Sebastian Sorge, et al.
Published: (2020-05-01)