Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver[S]

Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver[S]

Acyl-CoA thioesterase (Acot)2 localizes to the mitochondrial matrix and hydrolyses long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxi­dative tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role is unknown. Using a model of adenov...

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Bibliographic Details
Main Authors: Cynthia Moffat, Lavesh Bhatia, Teresa Nguyen, Peter Lynch, Miao Wang, Dongning Wang, Olga R. Ilkayeva, Xianlin Han, Matthew D. Hirschey, Steven M. Claypool, Erin L. Seifert
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Journal of Lipid Research
Subjects:
β-oxidation
mitochondria
mitochondrial thioesterase
mitochondrial proton leak
cardiolipin
mouse
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520366864

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