Sonochemotherapy: From bench to bedside
The combination of microbubbles and ultrasound has emerged as a promising method for local drug delivery. Microbubbles can be locally activated by a targeted ultrasound beam, which can result in several bio-effects. For drug delivery, microbubble-assisted ultrasound is used to increase vascular- and...
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2015-07-01
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doaj-3acc156976dc4da791b0de121b87b3442020-11-25T00:44:08ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122015-07-01610.3389/fphar.2015.00138150390Sonochemotherapy: From bench to bedsideBart eLammertink0Clemens eBos1Roel eDeckers2Gert eStorm3Gert eStorm4Chrit eMoonen5Jean-Michel eEscoffre6University Medical Center UtrechtUniversity Medical Center UtrechtUniversity Medical Center UtrechtUtrecht UniversityUniversity of TwenteUniversity Medical Center UtrechtUniversity Medical Center UtrechtThe combination of microbubbles and ultrasound has emerged as a promising method for local drug delivery. Microbubbles can be locally activated by a targeted ultrasound beam, which can result in several bio-effects. For drug delivery, microbubble-assisted ultrasound is used to increase vascular- and plasma membrane permeability for facilitating drug extravasation and the cellular uptake of drugs in the treated region, respectively. In the case of drug-loaded microbubbles, these two mechanisms can be combined with local release of the drug following destruction of the microbubble. The use of microbubble-assisted ultrasound to deliver chemotherapeutic agents is also referred to as sonochemotherapy. In this review, the basic principles of sonochemotherapy are discussed, including aspects such as the type of (drug-loaded) microbubbles used, the routes of administration used in vivo, ultrasound devices and parameters, treatment schedules and safety issues. Finally, the clinical translation of sonochemotherapy is discussed, including the first clinical study using sonochemotherapy.http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00138/fullDrug deliveryultrasoundPharmaceuticssonoporationMicrobubbleChemotherapeutic drug |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Bart eLammertink Clemens eBos Roel eDeckers Gert eStorm Gert eStorm Chrit eMoonen Jean-Michel eEscoffre |
spellingShingle |
Bart eLammertink Clemens eBos Roel eDeckers Gert eStorm Gert eStorm Chrit eMoonen Jean-Michel eEscoffre Sonochemotherapy: From bench to bedside Frontiers in Pharmacology Drug delivery ultrasound Pharmaceutics sonoporation Microbubble Chemotherapeutic drug |
author_facet |
Bart eLammertink Clemens eBos Roel eDeckers Gert eStorm Gert eStorm Chrit eMoonen Jean-Michel eEscoffre |
author_sort |
Bart eLammertink |
title |
Sonochemotherapy: From bench to bedside |
title_short |
Sonochemotherapy: From bench to bedside |
title_full |
Sonochemotherapy: From bench to bedside |
title_fullStr |
Sonochemotherapy: From bench to bedside |
title_full_unstemmed |
Sonochemotherapy: From bench to bedside |
title_sort |
sonochemotherapy: from bench to bedside |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Pharmacology |
issn |
1663-9812 |
publishDate |
2015-07-01 |
description |
The combination of microbubbles and ultrasound has emerged as a promising method for local drug delivery. Microbubbles can be locally activated by a targeted ultrasound beam, which can result in several bio-effects. For drug delivery, microbubble-assisted ultrasound is used to increase vascular- and plasma membrane permeability for facilitating drug extravasation and the cellular uptake of drugs in the treated region, respectively. In the case of drug-loaded microbubbles, these two mechanisms can be combined with local release of the drug following destruction of the microbubble. The use of microbubble-assisted ultrasound to deliver chemotherapeutic agents is also referred to as sonochemotherapy. In this review, the basic principles of sonochemotherapy are discussed, including aspects such as the type of (drug-loaded) microbubbles used, the routes of administration used in vivo, ultrasound devices and parameters, treatment schedules and safety issues. Finally, the clinical translation of sonochemotherapy is discussed, including the first clinical study using sonochemotherapy. |
topic |
Drug delivery ultrasound Pharmaceutics sonoporation Microbubble Chemotherapeutic drug |
url |
http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00138/full |
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