Vitamin D status and pulmonary exacerbations in children and adolescents with cystic fibrosis: Experience from a tertiary care center
Background: The function of Vitamin D in preventing inflammation and infection has been studied previously for different pathologies in different populations globally. Relationships between serum Vitamin D levels and its effect on pulmonary exacerbations in the cystic fibrosis (CF) population are no...
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Wolters Kluwer Medknow Publications
2021-01-01
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doaj-3adaf310bc474b45a07b26ff553b75812021-07-27T04:47:37ZengWolters Kluwer Medknow PublicationsLung India0970-21130974-598X2021-01-0138432632910.4103/lungindia.lungindia_589_20Vitamin D status and pulmonary exacerbations in children and adolescents with cystic fibrosis: Experience from a tertiary care centerDanish Abdul AzizSyeda Khadija FatimaHaissan IftikharFatima MirBackground: The function of Vitamin D in preventing inflammation and infection has been studied previously for different pathologies in different populations globally. Relationships between serum Vitamin D levels and its effect on pulmonary exacerbations in the cystic fibrosis (CF) population are not well studied in our part of the world. Therefore, we aimed to ascertain the Vitamin D status in pediatric and adolescent CF patients and its association with pulmonary exacerbations. Materials and Methods: A retrospective study was conducted at The Aga Khan University Hospital from 2015 to 2018. Patients of CF with sweat chloride value >60 mmol/l and who had at least one measurement of 25 hydroxy Vitamin D (25 OHD) were included in the study. Annual serum Vitamin D levels were documented for enrolled patients and their past 1-year data were analyzed for pulmonary exacerbations, average length of stay, and tracheal/airway colonization with organisms. Results: 69 patients were included in the study. 28 patients (40.57%) were found to be Vitamin D deficient, 22 patients (31.88%) were Vitamin D insufficient and 19 patients (27.53%) were labeled as Vitamin D insufficient. The average number of exacerbations per year was significantly high in Vitamin D deficient group (3.71 ± 0.96) in comparison with insufficient (3.18 ± 1.09) and sufficient groups (2.26 ± 0.93) (P < 0.001). Conclusion: Vitamin D deficiency is related to an increased number of annual pulmonary exacerbations and pseudomonas infections.http://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=4;spage=326;epage=329;aulast=Aziz25-hydroxyvitamin d (25-ohd)cystic fibrosispseudomonas colonizationpulmonary exacerbationsvitamin d deficiency |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Danish Abdul Aziz Syeda Khadija Fatima Haissan Iftikhar Fatima Mir |
spellingShingle |
Danish Abdul Aziz Syeda Khadija Fatima Haissan Iftikhar Fatima Mir Vitamin D status and pulmonary exacerbations in children and adolescents with cystic fibrosis: Experience from a tertiary care center Lung India 25-hydroxyvitamin d (25-ohd) cystic fibrosis pseudomonas colonization pulmonary exacerbations vitamin d deficiency |
author_facet |
Danish Abdul Aziz Syeda Khadija Fatima Haissan Iftikhar Fatima Mir |
author_sort |
Danish Abdul Aziz |
title |
Vitamin D status and pulmonary exacerbations in children and adolescents with cystic fibrosis: Experience from a tertiary care center |
title_short |
Vitamin D status and pulmonary exacerbations in children and adolescents with cystic fibrosis: Experience from a tertiary care center |
title_full |
Vitamin D status and pulmonary exacerbations in children and adolescents with cystic fibrosis: Experience from a tertiary care center |
title_fullStr |
Vitamin D status and pulmonary exacerbations in children and adolescents with cystic fibrosis: Experience from a tertiary care center |
title_full_unstemmed |
Vitamin D status and pulmonary exacerbations in children and adolescents with cystic fibrosis: Experience from a tertiary care center |
title_sort |
vitamin d status and pulmonary exacerbations in children and adolescents with cystic fibrosis: experience from a tertiary care center |
publisher |
Wolters Kluwer Medknow Publications |
series |
Lung India |
issn |
0970-2113 0974-598X |
publishDate |
2021-01-01 |
description |
Background: The function of Vitamin D in preventing inflammation and infection has been studied previously for different pathologies in different populations globally. Relationships between serum Vitamin D levels and its effect on pulmonary exacerbations in the cystic fibrosis (CF) population are not well studied in our part of the world. Therefore, we aimed to ascertain the Vitamin D status in pediatric and adolescent CF patients and its association with pulmonary exacerbations. Materials and Methods: A retrospective study was conducted at The Aga Khan University Hospital from 2015 to 2018. Patients of CF with sweat chloride value >60 mmol/l and who had at least one measurement of 25 hydroxy Vitamin D (25 OHD) were included in the study. Annual serum Vitamin D levels were documented for enrolled patients and their past 1-year data were analyzed for pulmonary exacerbations, average length of stay, and tracheal/airway colonization with organisms. Results: 69 patients were included in the study. 28 patients (40.57%) were found to be Vitamin D deficient, 22 patients (31.88%) were Vitamin D insufficient and 19 patients (27.53%) were labeled as Vitamin D insufficient. The average number of exacerbations per year was significantly high in Vitamin D deficient group (3.71 ± 0.96) in comparison with insufficient (3.18 ± 1.09) and sufficient groups (2.26 ± 0.93) (P < 0.001). Conclusion: Vitamin D deficiency is related to an increased number of annual pulmonary exacerbations and pseudomonas infections. |
topic |
25-hydroxyvitamin d (25-ohd) cystic fibrosis pseudomonas colonization pulmonary exacerbations vitamin d deficiency |
url |
http://www.lungindia.com/article.asp?issn=0970-2113;year=2021;volume=38;issue=4;spage=326;epage=329;aulast=Aziz |
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