Repeated Panniculitis Induced by Pegylated Interferon Alpha 2a in a Patient with Chronic Hepatitis C

• Main Authors: June Seok Song, Joo Hyun Sohn, Jae Yoon Jeong, Ji-Hee Min, Won Seok Choi, One Zoong Kim, Ju Yeon Pyo
• Format: Article
• Language: English
• Published: Jin Publishing & Printing Co. 2016-05-01
• Series: The Korean Journal of Gastroenterology
• Subjects: Panniculitis; Peginterferon alfa-2a; Hepatitis C; Adverse effects
• Online Access: http://www.kjg.or.kr/journal/view.html?doi=10.4166/kjg.2016.67.5.272

Pegylated interferon alpha (PEG-IFN-α) is widely used to treat chronic hepatitis C in combination with ribavirin. Many adverse effects of PEG-IFN-α, such as hematologic, psychologic, dermatologic, immunologic, and other abnormalities, have been reported, and some serious adverse events lead to PEG-IFN-α treatment discontinuation. For very rare adverse events such as panniculitis, there are no established guidelines on whether to continue PEG-IFN-α treatment. Published reports on panniculitis induced by PEG-IFN-α 2a are sparse. Herein we report a case of repeated occurrences of panniculitis in a patient with chronic hepatitis C, leading to treatment cessation. (Korean J Gastroenterol 2016;67:272-276