The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, Iran
<ul><li><strong>BACKGROUND</strong>: To determine the prevalence of metabolic syndrome in survivors of childhood leukemia in Isfahan, Iran.</li><li><strong>METHODS</strong>: During a 4-yea...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2009-04-01
|
Series: | Journal of Research in Medical Sciences |
Subjects: | |
Online Access: | http://journals.mui.ac.ir/jrms/article/view/2554 |
id |
doaj-3adce790019c47e281eaac6029e605f2 |
---|---|
record_format |
Article |
spelling |
doaj-3adce790019c47e281eaac6029e605f22020-11-25T01:51:44ZengWolters Kluwer Medknow PublicationsJournal of Research in Medical Sciences1735-19951735-71362009-04-01142111116The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, IranNahid ReisiAfshin AzhirMahin HashemipourPouran RaeissiAbasgholi AminiAlireza Moafi<ul><li><strong>BACKGROUND</strong>: To determine the prevalence of metabolic syndrome in survivors of childhood leukemia in Isfahan, Iran.</li><li><strong>METHODS</strong>: During a 4-year period (2003 to 2007), 55 children (33 male and 22 female) diagnosed with ALL at Unit of Hematology/ Oncology, Department of Pediatrics, Isfahan University of Medical Science, were enrolled in this crosssectional study. Metabolic syndrome was defined using the modified version of Adult Treatment Panel (ATP III) criteria. Insulin resistance was defined based on the homeostasis model assessment index (HOMA-IR).</li><li><strong>RESULTS</strong>: The mean age of participates was 10.4 years (range 6-19 years) and the mean interval since completion of chemotherapy was 35 months. Twenty percent (11/55) of survivors (10 male, 1 female) met criteria for diagnosis of metabolic syndrome. Obesity was observed in one forth of patients and nearly 3/4 of obese patients had metabolic syndrome. High serum insulin levels were found in 16% of participants and in 63% of obese survivors. The mean insulin levels in survivors with metabolic syndrome was three-times more than those without (28.3 mu/l vs. 9.57 mu/l, p = 0.004). Insulin resistance was detected in 72.7% of survivors with metabolic syndrome and it was&nbsp; ositively correlated with serum triglycerides (0.543, p < 0.001), systolic and diastolic BP (0.348, p = 0.01 and 0.368, p = 006 respectively), insulin levels (0.914, p < 0.001) and blood sugar (0.398, p = 003).</li><li><strong>CONCLUSIONS</strong>: The prevalence of metabolic syndrome in survivors of childhood leukemia in Iran is higher than developed countries. Nearly all of the obese patients had metabolic syndrome. Weight control and regular physical exercise are recommended to the survivors.</li><li><strong>KEYWORDS</strong>: Acute lymphoblastic leukemia, metabolic syndrome, obesity, children.</li></ul> http://journals.mui.ac.ir/jrms/article/view/2554Acute Lymphoblastic Leukemia, Metabolic syndrome, Obesity, children |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Nahid Reisi Afshin Azhir Mahin Hashemipour Pouran Raeissi Abasgholi Amini Alireza Moafi |
spellingShingle |
Nahid Reisi Afshin Azhir Mahin Hashemipour Pouran Raeissi Abasgholi Amini Alireza Moafi The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, Iran Journal of Research in Medical Sciences Acute Lymphoblastic Leukemia, Metabolic syndrome, Obesity, children |
author_facet |
Nahid Reisi Afshin Azhir Mahin Hashemipour Pouran Raeissi Abasgholi Amini Alireza Moafi |
author_sort |
Nahid Reisi |
title |
The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, Iran |
title_short |
The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, Iran |
title_full |
The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, Iran |
title_fullStr |
The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, Iran |
title_full_unstemmed |
The metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in Isfahan, Iran |
title_sort |
metabolic syndrome in survivors of childhood acute lymphoblastic leukemia in isfahan, iran |
publisher |
Wolters Kluwer Medknow Publications |
series |
Journal of Research in Medical Sciences |
issn |
1735-1995 1735-7136 |
publishDate |
2009-04-01 |
description |
<ul><li><strong>BACKGROUND</strong>: To determine the prevalence of metabolic syndrome in survivors of childhood leukemia in Isfahan, Iran.</li><li><strong>METHODS</strong>: During a 4-year period (2003 to 2007), 55 children (33 male and 22 female) diagnosed with ALL at Unit of Hematology/ Oncology, Department of Pediatrics, Isfahan University of Medical Science, were enrolled in this crosssectional study. Metabolic syndrome was defined using the modified version of Adult Treatment Panel (ATP III) criteria. Insulin resistance was defined based on the homeostasis model assessment index (HOMA-IR).</li><li><strong>RESULTS</strong>: The mean age of participates was 10.4 years (range 6-19 years) and the mean interval since completion of chemotherapy was 35 months. Twenty percent (11/55) of survivors (10 male, 1 female) met criteria for diagnosis of metabolic syndrome. Obesity was observed in one forth of patients and nearly 3/4 of obese patients had metabolic syndrome. High serum insulin levels were found in 16% of participants and in 63% of obese survivors. The mean insulin levels in survivors with metabolic syndrome was three-times more than those without (28.3 mu/l vs. 9.57 mu/l, p = 0.004). Insulin resistance was detected in 72.7% of survivors with metabolic syndrome and it was&nbsp; ositively correlated with serum triglycerides (0.543, p < 0.001), systolic and diastolic BP (0.348, p = 0.01 and 0.368, p = 006 respectively), insulin levels (0.914, p < 0.001) and blood sugar (0.398, p = 003).</li><li><strong>CONCLUSIONS</strong>: The prevalence of metabolic syndrome in survivors of childhood leukemia in Iran is higher than developed countries. Nearly all of the obese patients had metabolic syndrome. Weight control and regular physical exercise are recommended to the survivors.</li><li><strong>KEYWORDS</strong>: Acute lymphoblastic leukemia, metabolic syndrome, obesity, children.</li></ul> |
topic |
Acute Lymphoblastic Leukemia, Metabolic syndrome, Obesity, children |
url |
http://journals.mui.ac.ir/jrms/article/view/2554 |
work_keys_str_mv |
AT nahidreisi themetabolicsyndromeinsurvivorsofchildhoodacutelymphoblasticleukemiainisfahaniran AT afshinazhir themetabolicsyndromeinsurvivorsofchildhoodacutelymphoblasticleukemiainisfahaniran AT mahinhashemipour themetabolicsyndromeinsurvivorsofchildhoodacutelymphoblasticleukemiainisfahaniran AT pouranraeissi themetabolicsyndromeinsurvivorsofchildhoodacutelymphoblasticleukemiainisfahaniran AT abasgholiamini themetabolicsyndromeinsurvivorsofchildhoodacutelymphoblasticleukemiainisfahaniran AT alirezamoafi themetabolicsyndromeinsurvivorsofchildhoodacutelymphoblasticleukemiainisfahaniran AT nahidreisi metabolicsyndromeinsurvivorsofchildhoodacutelymphoblasticleukemiainisfahaniran AT afshinazhir metabolicsyndromeinsurvivorsofchildhoodacutelymphoblasticleukemiainisfahaniran AT mahinhashemipour metabolicsyndromeinsurvivorsofchildhoodacutelymphoblasticleukemiainisfahaniran AT pouranraeissi metabolicsyndromeinsurvivorsofchildhoodacutelymphoblasticleukemiainisfahaniran AT abasgholiamini metabolicsyndromeinsurvivorsofchildhoodacutelymphoblasticleukemiainisfahaniran AT alirezamoafi metabolicsyndromeinsurvivorsofchildhoodacutelymphoblasticleukemiainisfahaniran |
_version_ |
1724996664580636672 |