Clinical and economic analysis of macrocyclic gadolinium-based compounds for use in magnetic resonance imaging diagnostics
Gadolinium-based contrast compounds are paramagnetic chemicals that allow enhancing contrast during magnetic resonance imaging (MRI) tomographic investigation. It`s known that linear gadolinium-based paramagnetic compounds cause permanent accumulation of gadolinium in tissues. This effect is less pr...
Main Authors: | , |
---|---|
Format: | Article |
Language: | Russian |
Published: |
Izdatelstvo OKI
2020-01-01
|
Series: | Качественная клиническая практика |
Subjects: | |
Online Access: | https://www.clinvest.ru/jour/article/view/464 |
id |
doaj-3ade728010bb4236a5560d578f6bf0a9 |
---|---|
record_format |
Article |
spelling |
doaj-3ade728010bb4236a5560d578f6bf0a92020-11-25T03:09:34ZrusIzdatelstvo OKIКачественная клиническая практика2588-05192618-84732020-01-0103233110.24411/2588-0519-2019-10080453Clinical and economic analysis of macrocyclic gadolinium-based compounds for use in magnetic resonance imaging diagnosticsA. E. Cheberda0D. U. Belousov1LLC «Center for pharmacoeconomics research»LLC «Center for pharmacoeconomics research»Gadolinium-based contrast compounds are paramagnetic chemicals that allow enhancing contrast during magnetic resonance imaging (MRI) tomographic investigation. It`s known that linear gadolinium-based paramagnetic compounds cause permanent accumulation of gadolinium in tissues. This effect is less pronounced in macrocyclic gadolinium-based compounds, which makes them increasingly relevant.Aim. Evaluate clinical and economic analysis of macrocyclic gadolinium-based contrast gadoteridol compared with gadobutrol for MRI diagnostics.Methodology. Decision tree model with one-year time horizon was constructed. Model accounted for specific parameters of administration of each of compared contrasts. Only direct medical costs evaluated. The number of detected anomalies selected as effectiveness criterion. We used cost minimization analysis (CMA) because there were no differences in effectiveness. Then we performed the budget impact analysis (BIA), accounting to number of patients receiving MRI of brain in the Russian Federation. Relevant sensitivity analyses carried out.Result. Gadoteridol was superior both in CMA (cost reduction reached 21.51 %) and BIA (budget burden reduced by 10.31 % which amounts to 15 735 332 rubles). Sensitivity analysis confirms the model robustness.Conclusion. Clinical and economic analysis of gadoteridol compared with gadobutrol demonstrated that expansion of gadoteridol use in Russian healthcare is economically feasible.https://www.clinvest.ru/jour/article/view/464gadoteridolgadobutroltomographypharmacoeconomicscost minimization analysisbudget impact analysis |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
A. E. Cheberda D. U. Belousov |
spellingShingle |
A. E. Cheberda D. U. Belousov Clinical and economic analysis of macrocyclic gadolinium-based compounds for use in magnetic resonance imaging diagnostics Качественная клиническая практика gadoteridol gadobutrol tomography pharmacoeconomics cost minimization analysis budget impact analysis |
author_facet |
A. E. Cheberda D. U. Belousov |
author_sort |
A. E. Cheberda |
title |
Clinical and economic analysis of macrocyclic gadolinium-based compounds for use in magnetic resonance imaging diagnostics |
title_short |
Clinical and economic analysis of macrocyclic gadolinium-based compounds for use in magnetic resonance imaging diagnostics |
title_full |
Clinical and economic analysis of macrocyclic gadolinium-based compounds for use in magnetic resonance imaging diagnostics |
title_fullStr |
Clinical and economic analysis of macrocyclic gadolinium-based compounds for use in magnetic resonance imaging diagnostics |
title_full_unstemmed |
Clinical and economic analysis of macrocyclic gadolinium-based compounds for use in magnetic resonance imaging diagnostics |
title_sort |
clinical and economic analysis of macrocyclic gadolinium-based compounds for use in magnetic resonance imaging diagnostics |
publisher |
Izdatelstvo OKI |
series |
Качественная клиническая практика |
issn |
2588-0519 2618-8473 |
publishDate |
2020-01-01 |
description |
Gadolinium-based contrast compounds are paramagnetic chemicals that allow enhancing contrast during magnetic resonance imaging (MRI) tomographic investigation. It`s known that linear gadolinium-based paramagnetic compounds cause permanent accumulation of gadolinium in tissues. This effect is less pronounced in macrocyclic gadolinium-based compounds, which makes them increasingly relevant.Aim. Evaluate clinical and economic analysis of macrocyclic gadolinium-based contrast gadoteridol compared with gadobutrol for MRI diagnostics.Methodology. Decision tree model with one-year time horizon was constructed. Model accounted for specific parameters of administration of each of compared contrasts. Only direct medical costs evaluated. The number of detected anomalies selected as effectiveness criterion. We used cost minimization analysis (CMA) because there were no differences in effectiveness. Then we performed the budget impact analysis (BIA), accounting to number of patients receiving MRI of brain in the Russian Federation. Relevant sensitivity analyses carried out.Result. Gadoteridol was superior both in CMA (cost reduction reached 21.51 %) and BIA (budget burden reduced by 10.31 % which amounts to 15 735 332 rubles). Sensitivity analysis confirms the model robustness.Conclusion. Clinical and economic analysis of gadoteridol compared with gadobutrol demonstrated that expansion of gadoteridol use in Russian healthcare is economically feasible. |
topic |
gadoteridol gadobutrol tomography pharmacoeconomics cost minimization analysis budget impact analysis |
url |
https://www.clinvest.ru/jour/article/view/464 |
work_keys_str_mv |
AT aecheberda clinicalandeconomicanalysisofmacrocyclicgadoliniumbasedcompoundsforuseinmagneticresonanceimagingdiagnostics AT dubelousov clinicalandeconomicanalysisofmacrocyclicgadoliniumbasedcompoundsforuseinmagneticresonanceimagingdiagnostics |
_version_ |
1724661872847749120 |