Fatty Liver Due to Increased de novo Lipogenesis: Alterations in the Hepatic Peroxisomal Proteome

Fatty Liver Due to Increased de novo Lipogenesis: Alterations in the Hepatic Peroxisomal Proteome

In non-alcoholic fatty liver disease (NAFLD) caused by ectopic lipid accumulation, lipotoxicity is a crucial molecular risk factor. Mechanisms to eliminate lipid overflow can prevent the liver from functional complications. This may involve increased secretion of lipids or metabolic adaptation to ß-...

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Bibliographic Details
Main Authors: Birgit Knebel, Pia Fahlbusch, Matthias Dille, Natalie Wahlers, Sonja Hartwig, Sylvia Jacob, Ulrike Kettel, Martina Schiller, Diran Herebian, Cornelia Koellmer, Stefan Lehr, Dirk Müller-Wieland, Jorg Kotzka
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
NAFLD
fatty liver
peroxisomes
label-free proteomic profiling
transcriptomics
lipidomics
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00248/full

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