Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-induced Senescence

Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-induced Senescence

Aging is a major risk factor for many neurodegenerative disorders. A key feature of aging biology that may underlie these diseases is cellular senescence. Senescent cells accumulate in tissues with age, undergo widespread changes in gene expression, and typically demonstrate altered, pro-inflammator...

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Bibliographic Details
Main Authors: Elizabeth P. Crowe, Ferit Tuzer, Brian D. Gregory, Greg Donahue, Sager J. Gosai, Justin Cohen, Yuk Yee Leung, Emre Yetkin, Raffaella Nativio, Li-San Wang, Christian Sell, Nancy M. Bonini, Shelley L. Berger, F Brad Johnson, Claudio Torres
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Brain aging
RNA sequencing
Brain oxidative stress
Astrocyte senescence
Astrocyte function
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00208/full

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