In vitro study of sirolimus release from nonwoven PLLA matrices

• Main Authors: Illner Sabine, Kohse Stefanie, Michaelis Claudia, Reske Thomas, Grabow Niels, Schmitz Klaus-Peter, Eickner Thomas
• Format: Article
• Language: English
• Published: De Gruyter 2018-09-01
• Series: Current Directions in Biomedical Engineering
• Subjects: drug release; fibrous material; nonwoven; film layer; surface modification; hydrophilization
• Online Access: https://doi.org/10.1515/cdbme-2018-0142

Sirolimus incorporated nonwoven polymer matrices were fabricated via electrospinning. Release kinetics considering different fiber diameters and layer thicknesses were investigated. In vitro drug release profiles were evaluated by measuring the drug concentration in an established drug release medium (0.9% saline solution with additives, not buffered) at predetermined time points. Furthermore, an NH3-plasma pretreatment was examined to ensure complete wetting from the beginning of the study. In comparison to thin drug-loaded PLLA spray coatings it was shown that the release of sirolimus is diffusion- and degradation-controlled regardless of the surface-to-volume ratio, though fiber diameters or a hydrophilization can affect its release kinetics.