A pilot study for control of hyperendemic cystic hydatid disease in China.
BACKGROUND: Cystic hydatid disease (CHD) is a global parasitic zoonosis caused by the dog tapeworm, Echinococcus granulosus. The disease is hyperendemic in western China because of poor economic development; limited community knowledge of CHD; widespread, small-scale household animal production; hom...
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doaj-3aed9858779c494e9593d0324c7376c32020-11-25T01:20:05ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352009-01-01310e53410.1371/journal.pntd.0000534A pilot study for control of hyperendemic cystic hydatid disease in China.Wenbao ZhangZhuangzhi ZhangTurhong YimitBaoxin ShiHasyeti AiliGulnor TulsonHong YouJun LiDarren J GrayDonald P McManusJincheng WangBACKGROUND: Cystic hydatid disease (CHD) is a global parasitic zoonosis caused by the dog tapeworm, Echinococcus granulosus. The disease is hyperendemic in western China because of poor economic development; limited community knowledge of CHD; widespread, small-scale household animal production; home killing of livestock; and the feeding of dogs with uncooked offal. METHODOLOGY/PRINCIPAL FINDINGS: A control program focusing on monthly praziquantel (PZQ) treatment of all registered dogs and culling unwanted and stray dogs has been designed to control CHD in hyperendemic areas in China. A pilot field control project in two counties (Hutubi and Wensu) in Xinjiang, China showed that after 4 years of treatment, the prevalence of dogs with E. granulosus was reduced from 14.7% and 18.6%, respectively, to 0%, and this caused a 90%-100% decrease of CHD in sheep born after commencement of the control program. CONCLUSIONS/SIGNIFICANCE: The strategy aimed at preventing eggs being released from dogs into the environment by treating animals before adult tapeworms are patent can decrease E. granulosus transmission and considerably reduce hyperendemic CHD. Monthly treatment of dogs with PZQ and culling unwanted and stray dogs have been shown to be an efficient, highly cost-effective and practicable measure for implementation in rural communities. As a result, the Chinese Ministry of Health has launched an extensive CHD control program in 117 counties in western China using this control strategy.http://europepmc.org/articles/PMC2761615?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenbao Zhang Zhuangzhi Zhang Turhong Yimit Baoxin Shi Hasyeti Aili Gulnor Tulson Hong You Jun Li Darren J Gray Donald P McManus Jincheng Wang |
spellingShingle |
Wenbao Zhang Zhuangzhi Zhang Turhong Yimit Baoxin Shi Hasyeti Aili Gulnor Tulson Hong You Jun Li Darren J Gray Donald P McManus Jincheng Wang A pilot study for control of hyperendemic cystic hydatid disease in China. PLoS Neglected Tropical Diseases |
author_facet |
Wenbao Zhang Zhuangzhi Zhang Turhong Yimit Baoxin Shi Hasyeti Aili Gulnor Tulson Hong You Jun Li Darren J Gray Donald P McManus Jincheng Wang |
author_sort |
Wenbao Zhang |
title |
A pilot study for control of hyperendemic cystic hydatid disease in China. |
title_short |
A pilot study for control of hyperendemic cystic hydatid disease in China. |
title_full |
A pilot study for control of hyperendemic cystic hydatid disease in China. |
title_fullStr |
A pilot study for control of hyperendemic cystic hydatid disease in China. |
title_full_unstemmed |
A pilot study for control of hyperendemic cystic hydatid disease in China. |
title_sort |
pilot study for control of hyperendemic cystic hydatid disease in china. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Neglected Tropical Diseases |
issn |
1935-2727 1935-2735 |
publishDate |
2009-01-01 |
description |
BACKGROUND: Cystic hydatid disease (CHD) is a global parasitic zoonosis caused by the dog tapeworm, Echinococcus granulosus. The disease is hyperendemic in western China because of poor economic development; limited community knowledge of CHD; widespread, small-scale household animal production; home killing of livestock; and the feeding of dogs with uncooked offal. METHODOLOGY/PRINCIPAL FINDINGS: A control program focusing on monthly praziquantel (PZQ) treatment of all registered dogs and culling unwanted and stray dogs has been designed to control CHD in hyperendemic areas in China. A pilot field control project in two counties (Hutubi and Wensu) in Xinjiang, China showed that after 4 years of treatment, the prevalence of dogs with E. granulosus was reduced from 14.7% and 18.6%, respectively, to 0%, and this caused a 90%-100% decrease of CHD in sheep born after commencement of the control program. CONCLUSIONS/SIGNIFICANCE: The strategy aimed at preventing eggs being released from dogs into the environment by treating animals before adult tapeworms are patent can decrease E. granulosus transmission and considerably reduce hyperendemic CHD. Monthly treatment of dogs with PZQ and culling unwanted and stray dogs have been shown to be an efficient, highly cost-effective and practicable measure for implementation in rural communities. As a result, the Chinese Ministry of Health has launched an extensive CHD control program in 117 counties in western China using this control strategy. |
url |
http://europepmc.org/articles/PMC2761615?pdf=render |
work_keys_str_mv |
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