DEHP Down-Regulates Tshr Gene Expression in Rat Thyroid Tissues and FRTL-5 Rat Thyrocytes: A Potential Mechanism of Thyroid Disruption

DEHP Down-Regulates Tshr Gene Expression in Rat Thyroid Tissues and FRTL-5 Rat Thyrocytes: A Potential Mechanism of Thyroid Disruption

Background Di-2-ethylhexyl phthalate (DEHP) is known to disrupt thyroid hormonal status. However, the underlying molecular mechanism of this disruption is unclear. Therefore, we investigated the direct effects of DEHP on the thyroid gland. Methods DEHP (vehicle, 50 mg/kg, and 500 mg/kg) was administ...

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Bibliographic Details
Main Authors: Min Joo Kim, Hwan Hee Kim, Young Shin Song, Ok-Hee Kim, Kyungho Choi, Sujin Kim, Byung-Chul Oh, Young Joo Park
Format: Article
Language:English
Published: Academya Publishing Co. 2021-04-01
Series:Endocrinology and Metabolism
Subjects:
diethylhexyl phthalate
endocrine disruptors
thyroid gland
receptors
thyrotropin
Online Access:http://www.e-enm.org/upload/pdf/enm-2020-920.pdf

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