Hypnotic drug risks of mortality, infection, depression, and cancer: but lack of benefit [version 3; referees: 2 approved]

• Main Author: Daniel F. Kripke
• Format: Article
• Language: English
• Published: F1000 Research Ltd 2018-11-01
• Series: F1000Research
• Subjects: Anxiety Disorders; Mood Disorders; Neuropharmacology & Psychopharmacology; Neuropsychiatric Disorders
• Online Access: https://f1000research.com/articles/5-918/v3

This is a review of hypnotic drug risks and benefits. Almost every month, new information appears about the risks of hypnotics (sleeping pills). The most important risks of hypnotics include excess mortality (especially overdose deaths, quiet deaths at night, and suicides), infections, cancer, depression, automobile crashes, falls, other accidents, and hypnotic-withdrawal insomnia. Short-term use of one-two prescriptions is associated with even greater risk per dose than long-term use. Hypnotics have usually been prescribed without approved indication, most often with specific contraindications, but even when indicated, there is little or no benefit. The recommended doses objectively increase sleep little if at all, daytime performance is often made worse (not better) and the lack of general health benefits is commonly misrepresented in advertising. Treatments such as the cognitive behavioral treatment of insomnia and bright light treatment of circadian rhythm disorders offer safer and more effective alternative approaches to insomnia.