Genetyka łuszczycy – od badań serologicznych antygenów zgodności tkankowej do badań asocjacyjnych całego genomu
Psoriasis is a complex disease with multifactorial mode of inheritance,whichmeans that its clinicalmanifestations depend uponmultiple genesinteracting with environmental agents. The major genetic factor responsiblefor 35-50% susceptibility for early psoriasis in the Caucasian population,HLA-Cw*06, i...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2011-11-01
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| Series: | Przegląd Dermatologiczny |
| Subjects: | |
| Online Access: | http://www.termedia.pl/Prace-specjalne-Genetyka-luszczycy-od-badan-serologicznych-antygenow-zgodnosci-tkankowej-r-ndo-badan-asocjacyjnych-calego-genomu,56,17698,1,0.html |
| Summary: | Psoriasis is a complex disease with multifactorial mode of inheritance,whichmeans that its clinicalmanifestations depend uponmultiple genesinteracting with environmental agents. The major genetic factor responsiblefor 35-50% susceptibility for early psoriasis in the Caucasian population,HLA-Cw*06, is located within the major histocompatibility complex(MHC) on the sixth chromosome. Whole genome associationstudies, the newest research trend, revealed three genetic, non-MHCrelated pathways connected with psoriasis susceptibility: Th17, Th2 andNF-κB-dependent. These genes are responsible for inflammation, epidermalproliferation and epidermal barrier function in psoriasis. |
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| ISSN: | 0033-2526 |