Oxidative stress in mammalian cells impinges on the cysteines redox state of human XRCC3 protein and on its cellular localization.

Oxidative stress in mammalian cells impinges on the cysteines redox state of human XRCC3 protein and on its cellular localization.

In vertebrates, XRCC3 is one of the five Rad51 paralogs that plays a central role in homologous recombination (HR), a key pathway for maintaining genomic stability. While investigating the potential role of human XRCC3 (hXRCC3) in the inhibition of DNA replication induced by UVA radiation, we discov...

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Bibliographic Details
Main Authors: Pierre-Marie Girard, Dany Graindorge, Violetta Smirnova, Pascal Rigolet, Stefania Francesconi, Susan Scanlon, Evelyne Sage
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3793007?pdf=render

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http://europepmc.org/articles/PMC3793007?pdf=render

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