The value of IgG to IgM ratio in predicting secondary dengue infection
Background The determination of primary or secondary dengue infection using hemagglutination inhibition (HI) test is time-con- suming. The IgG to IgM ratio which can be obtained earlier was used by several studies to differentiate secondary from primary infection, but they still reported various cut...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
Indonesian Pediatric Society Publishing House
2016-10-01
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Series: | Paediatrica Indonesiana |
Subjects: | |
Online Access: | https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/911 |
Summary: | Background The determination of primary or secondary dengue
infection using hemagglutination inhibition (HI) test is time-con-
suming. The IgG to IgM ratio which can be obtained earlier was
used by several studies to differentiate secondary from primary
infection, but they still reported various cut-off points.
Objective To find the diagnostic value and best cut off point of
IgG to IgM ratio for predicting secondary dengue infection.
Methods This was a prospective study carried out between July
2003 and June 2004. Children with suspected dengue hemor-
rhagic fever (DHF) were tested for HI during acute and convales-
cent phase. The IgG and IgM titer were examined during the acute
phase using ELISA method.
Results Sixty-two children were recruited, 48 with secondary in-
fection and 14 with primary infection. The prevalence of second-
ary infection was 77%. The best cut off point of the IgG to IgM ratio
to predict secondary infection was >1.1 with sensitivity of 87.5%,
specificity 92.9%, likelihood ratio 12.3, and post test probability
97.7%.
Conclusion The IgG to IgM ratio of >1.1 is a good predictor for
secondary infection |
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ISSN: | 0030-9311 2338-476X |