The value of IgG to IgM ratio in predicting secondary dengue infection

Background The determination of primary or secondary dengue infection using hemagglutination inhibition (HI) test is time-con- suming. The IgG to IgM ratio which can be obtained earlier was used by several studies to differentiate secondary from primary infection, but they still reported various cut...

Full description

Bibliographic Details
Main Authors: I Putu Gede Karyana, Hendra Santoso, Bagus Ngurah Putu Arhana
Format: Article
Language:English
Published: Indonesian Pediatric Society Publishing House 2016-10-01
Series:Paediatrica Indonesiana
Subjects:
Online Access:https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/911
id doaj-3b167b326cee4f10be1d5559f708fdb9
record_format Article
spelling doaj-3b167b326cee4f10be1d5559f708fdb92020-11-24T21:18:27ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2016-10-01463113710.14238/pi46.3.2006.113-7769The value of IgG to IgM ratio in predicting secondary dengue infectionI Putu Gede KaryanaHendra SantosoBagus Ngurah Putu ArhanaBackground The determination of primary or secondary dengue infection using hemagglutination inhibition (HI) test is time-con- suming. The IgG to IgM ratio which can be obtained earlier was used by several studies to differentiate secondary from primary infection, but they still reported various cut-off points. Objective To find the diagnostic value and best cut off point of IgG to IgM ratio for predicting secondary dengue infection. Methods This was a prospective study carried out between July 2003 and June 2004. Children with suspected dengue hemor- rhagic fever (DHF) were tested for HI during acute and convales- cent phase. The IgG and IgM titer were examined during the acute phase using ELISA method. Results Sixty-two children were recruited, 48 with secondary in- fection and 14 with primary infection. The prevalence of second- ary infection was 77%. The best cut off point of the IgG to IgM ratio to predict secondary infection was >1.1 with sensitivity of 87.5%, specificity 92.9%, likelihood ratio 12.3, and post test probability 97.7%. Conclusion The IgG to IgM ratio of >1.1 is a good predictor for secondary infectionhttps://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/911dengue hemorrhagic fever (DHF)primary and secondary infectionhemagglutination inhibition (HI) testratio of IgG:IgM
collection DOAJ
language English
format Article
sources DOAJ
author I Putu Gede Karyana
Hendra Santoso
Bagus Ngurah Putu Arhana
spellingShingle I Putu Gede Karyana
Hendra Santoso
Bagus Ngurah Putu Arhana
The value of IgG to IgM ratio in predicting secondary dengue infection
Paediatrica Indonesiana
dengue hemorrhagic fever (DHF)
primary and secondary infection
hemagglutination inhibition (HI) test
ratio of IgG:IgM
author_facet I Putu Gede Karyana
Hendra Santoso
Bagus Ngurah Putu Arhana
author_sort I Putu Gede Karyana
title The value of IgG to IgM ratio in predicting secondary dengue infection
title_short The value of IgG to IgM ratio in predicting secondary dengue infection
title_full The value of IgG to IgM ratio in predicting secondary dengue infection
title_fullStr The value of IgG to IgM ratio in predicting secondary dengue infection
title_full_unstemmed The value of IgG to IgM ratio in predicting secondary dengue infection
title_sort value of igg to igm ratio in predicting secondary dengue infection
publisher Indonesian Pediatric Society Publishing House
series Paediatrica Indonesiana
issn 0030-9311
2338-476X
publishDate 2016-10-01
description Background The determination of primary or secondary dengue infection using hemagglutination inhibition (HI) test is time-con- suming. The IgG to IgM ratio which can be obtained earlier was used by several studies to differentiate secondary from primary infection, but they still reported various cut-off points. Objective To find the diagnostic value and best cut off point of IgG to IgM ratio for predicting secondary dengue infection. Methods This was a prospective study carried out between July 2003 and June 2004. Children with suspected dengue hemor- rhagic fever (DHF) were tested for HI during acute and convales- cent phase. The IgG and IgM titer were examined during the acute phase using ELISA method. Results Sixty-two children were recruited, 48 with secondary in- fection and 14 with primary infection. The prevalence of second- ary infection was 77%. The best cut off point of the IgG to IgM ratio to predict secondary infection was >1.1 with sensitivity of 87.5%, specificity 92.9%, likelihood ratio 12.3, and post test probability 97.7%. Conclusion The IgG to IgM ratio of >1.1 is a good predictor for secondary infection
topic dengue hemorrhagic fever (DHF)
primary and secondary infection
hemagglutination inhibition (HI) test
ratio of IgG:IgM
url https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/911
work_keys_str_mv AT iputugedekaryana thevalueofiggtoigmratioinpredictingsecondarydengueinfection
AT hendrasantoso thevalueofiggtoigmratioinpredictingsecondarydengueinfection
AT bagusngurahputuarhana thevalueofiggtoigmratioinpredictingsecondarydengueinfection
AT iputugedekaryana valueofiggtoigmratioinpredictingsecondarydengueinfection
AT hendrasantoso valueofiggtoigmratioinpredictingsecondarydengueinfection
AT bagusngurahputuarhana valueofiggtoigmratioinpredictingsecondarydengueinfection
_version_ 1726009179541340160