14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila

14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila

14-3-3 proteins regulate several signalling pathways but often act redundantly; however, the molecular mechanisms behind such redundancy are unclear. Here, the authors show that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, Tctp and Rheb, disrupting organ devel...

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Main Authors: Thao Phuong Le, Linh Thuong Vuong, Ah-Ram Kim, Ya-Chieh Hsu, Kwang-Wook Choi
Format: Article
Language:English
Published: Nature Publishing Group 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11501
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spelling doaj-3b1e8c0b1da148e8a191c239633cbfee2021-05-11T10:54:08ZengNature Publishing GroupNature Communications2041-17232016-05-017111010.1038/ncomms1150114-3-3 proteins regulate Tctp–Rheb interaction for organ growth in DrosophilaThao Phuong Le0Linh Thuong Vuong1Ah-Ram Kim2Ya-Chieh Hsu3Kwang-Wook Choi4Department of Biological Sciences, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences, Korea Advanced Institute of Science and TechnologyDepartment of Biological Sciences, Korea Advanced Institute of Science and TechnologyDepartment of Stem Cell and Regenerative Biology, Harvard University, Sherman Fairchild 358ADepartment of Biological Sciences, Korea Advanced Institute of Science and Technology14-3-3 proteins regulate several signalling pathways but often act redundantly; however, the molecular mechanisms behind such redundancy are unclear. Here, the authors show that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, Tctp and Rheb, disrupting organ development.https://doi.org/10.1038/ncomms11501
collection DOAJ
language English
format Article
sources DOAJ
author Thao Phuong Le
Linh Thuong Vuong
Ah-Ram Kim
Ya-Chieh Hsu
Kwang-Wook Choi
spellingShingle Thao Phuong Le
Linh Thuong Vuong
Ah-Ram Kim
Ya-Chieh Hsu
Kwang-Wook Choi
14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila
Nature Communications
author_facet Thao Phuong Le
Linh Thuong Vuong
Ah-Ram Kim
Ya-Chieh Hsu
Kwang-Wook Choi
author_sort Thao Phuong Le
title 14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila
title_short 14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila
title_full 14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila
title_fullStr 14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila
title_full_unstemmed 14-3-3 proteins regulate Tctp–Rheb interaction for organ growth in Drosophila
title_sort 14-3-3 proteins regulate tctp–rheb interaction for organ growth in drosophila
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-05-01
description 14-3-3 proteins regulate several signalling pathways but often act redundantly; however, the molecular mechanisms behind such redundancy are unclear. Here, the authors show that 14-3-3 proteins regulate two interacting components of Tor signalling in Drosophila, Tctp and Rheb, disrupting organ development.
url https://doi.org/10.1038/ncomms11501
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AT linhthuongvuong 1433proteinsregulatetctprhebinteractionfororgangrowthindrosophila
AT ahramkim 1433proteinsregulatetctprhebinteractionfororgangrowthindrosophila
AT yachiehhsu 1433proteinsregulatetctprhebinteractionfororgangrowthindrosophila
AT kwangwookchoi 1433proteinsregulatetctprhebinteractionfororgangrowthindrosophila
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