Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
Abstract The change in ambient temperature is one of the risk factors for the aggravation of bronchial asthma (BA). Yet, whether the ambient temperature influences the immune functions associated with allergic asthma remains unknown. In this study, we treated asthmatic mice with standard temperature...
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doaj-3b291b96678e47e0bc98a9609f65d3082020-12-08T00:29:06ZengNature Publishing GroupScientific Reports2045-23222017-08-01711810.1038/s41598-017-07471-7Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in miceWenjing Liao0Libo Zhou1Xiaolong Zhao2Lijuan Song3Yingshen Lu4Nanshan Zhong5Pingchang Yang6Baoqing Sun7Xiaowen Zhang8State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryDepartment of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryDepartment of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryAbstract The change in ambient temperature is one of the risk factors for the aggravation of bronchial asthma (BA). Yet, whether the ambient temperature influences the immune functions associated with allergic asthma remains unknown. In this study, we treated asthmatic mice with standard temperature (ST, 20 °C) or thermoneutral temperature (TT, 30 °C). The results showed that the airway inflammatory cell counts in bronchoalveolar lavage fluid (BALF) and airway hyperresponsiveness (AHR) were significantly reduced in the mice treated with TT as compared with the mice treated with ST. The imbalance of Th1/Th2 response in the lung was improved following housing the mice at TT. In addition, the pulmonary Treg cells were increased in asthmatic mice after TT treatment. The temperature stress (29 °C and 41 °C) drove naïve CD4T cells towards Th2 cells. Our data demonstrate that the change of ambient temperature was a risk factor to aggravate experimental asthma.https://doi.org/10.1038/s41598-017-07471-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenjing Liao Libo Zhou Xiaolong Zhao Lijuan Song Yingshen Lu Nanshan Zhong Pingchang Yang Baoqing Sun Xiaowen Zhang |
spellingShingle |
Wenjing Liao Libo Zhou Xiaolong Zhao Lijuan Song Yingshen Lu Nanshan Zhong Pingchang Yang Baoqing Sun Xiaowen Zhang Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice Scientific Reports |
author_facet |
Wenjing Liao Libo Zhou Xiaolong Zhao Lijuan Song Yingshen Lu Nanshan Zhong Pingchang Yang Baoqing Sun Xiaowen Zhang |
author_sort |
Wenjing Liao |
title |
Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice |
title_short |
Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice |
title_full |
Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice |
title_fullStr |
Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice |
title_full_unstemmed |
Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice |
title_sort |
thermoneutral housing temperature regulates t-regulatory cell function and inhibits ovabumin-induced asthma development in mice |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2017-08-01 |
description |
Abstract The change in ambient temperature is one of the risk factors for the aggravation of bronchial asthma (BA). Yet, whether the ambient temperature influences the immune functions associated with allergic asthma remains unknown. In this study, we treated asthmatic mice with standard temperature (ST, 20 °C) or thermoneutral temperature (TT, 30 °C). The results showed that the airway inflammatory cell counts in bronchoalveolar lavage fluid (BALF) and airway hyperresponsiveness (AHR) were significantly reduced in the mice treated with TT as compared with the mice treated with ST. The imbalance of Th1/Th2 response in the lung was improved following housing the mice at TT. In addition, the pulmonary Treg cells were increased in asthmatic mice after TT treatment. The temperature stress (29 °C and 41 °C) drove naïve CD4T cells towards Th2 cells. Our data demonstrate that the change of ambient temperature was a risk factor to aggravate experimental asthma. |
url |
https://doi.org/10.1038/s41598-017-07471-7 |
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