Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice

Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice

Abstract The change in ambient temperature is one of the risk factors for the aggravation of bronchial asthma (BA). Yet, whether the ambient temperature influences the immune functions associated with allergic asthma remains unknown. In this study, we treated asthmatic mice with standard temperature...

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Main Authors: Wenjing Liao, Libo Zhou, Xiaolong Zhao, Lijuan Song, Yingshen Lu, Nanshan Zhong, Pingchang Yang, Baoqing Sun, Xiaowen Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2017-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-07471-7
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spelling doaj-3b291b96678e47e0bc98a9609f65d3082020-12-08T00:29:06ZengNature Publishing GroupScientific Reports2045-23222017-08-01711810.1038/s41598-017-07471-7Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in miceWenjing Liao0Libo Zhou1Xiaolong Zhao2Lijuan Song3Yingshen Lu4Nanshan Zhong5Pingchang Yang6Baoqing Sun7Xiaowen Zhang8State Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryDepartment of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryDepartment of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease, Department of Otolaryngology-Head and Neck SurgeryAbstract The change in ambient temperature is one of the risk factors for the aggravation of bronchial asthma (BA). Yet, whether the ambient temperature influences the immune functions associated with allergic asthma remains unknown. In this study, we treated asthmatic mice with standard temperature (ST, 20 °C) or thermoneutral temperature (TT, 30 °C). The results showed that the airway inflammatory cell counts in bronchoalveolar lavage fluid (BALF) and airway hyperresponsiveness (AHR) were significantly reduced in the mice treated with TT as compared with the mice treated with ST. The imbalance of Th1/Th2 response in the lung was improved following housing the mice at TT. In addition, the pulmonary Treg cells were increased in asthmatic mice after TT treatment. The temperature stress (29 °C and 41 °C) drove naïve CD4T cells towards Th2 cells. Our data demonstrate that the change of ambient temperature was a risk factor to aggravate experimental asthma.https://doi.org/10.1038/s41598-017-07471-7
collection DOAJ
language English
format Article
sources DOAJ
author Wenjing Liao
Libo Zhou
Xiaolong Zhao
Lijuan Song
Yingshen Lu
Nanshan Zhong
Pingchang Yang
Baoqing Sun
Xiaowen Zhang
spellingShingle Wenjing Liao
Libo Zhou
Xiaolong Zhao
Lijuan Song
Yingshen Lu
Nanshan Zhong
Pingchang Yang
Baoqing Sun
Xiaowen Zhang
Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
Scientific Reports
author_facet Wenjing Liao
Libo Zhou
Xiaolong Zhao
Lijuan Song
Yingshen Lu
Nanshan Zhong
Pingchang Yang
Baoqing Sun
Xiaowen Zhang
author_sort Wenjing Liao
title Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
title_short Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
title_full Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
title_fullStr Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
title_full_unstemmed Thermoneutral housing temperature regulates T-regulatory cell function and inhibits ovabumin-induced asthma development in mice
title_sort thermoneutral housing temperature regulates t-regulatory cell function and inhibits ovabumin-induced asthma development in mice
publisher Nature Publishing Group
series Scientific Reports
issn 2045-2322
publishDate 2017-08-01
description Abstract The change in ambient temperature is one of the risk factors for the aggravation of bronchial asthma (BA). Yet, whether the ambient temperature influences the immune functions associated with allergic asthma remains unknown. In this study, we treated asthmatic mice with standard temperature (ST, 20 °C) or thermoneutral temperature (TT, 30 °C). The results showed that the airway inflammatory cell counts in bronchoalveolar lavage fluid (BALF) and airway hyperresponsiveness (AHR) were significantly reduced in the mice treated with TT as compared with the mice treated with ST. The imbalance of Th1/Th2 response in the lung was improved following housing the mice at TT. In addition, the pulmonary Treg cells were increased in asthmatic mice after TT treatment. The temperature stress (29 °C and 41 °C) drove naïve CD4T cells towards Th2 cells. Our data demonstrate that the change of ambient temperature was a risk factor to aggravate experimental asthma.
url https://doi.org/10.1038/s41598-017-07471-7
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AT libozhou thermoneutralhousingtemperatureregulatestregulatorycellfunctionandinhibitsovabumininducedasthmadevelopmentinmice
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AT yingshenlu thermoneutralhousingtemperatureregulatestregulatorycellfunctionandinhibitsovabumininducedasthmadevelopmentinmice
AT nanshanzhong thermoneutralhousingtemperatureregulatestregulatorycellfunctionandinhibitsovabumininducedasthmadevelopmentinmice
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