Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice

Paneth cell ablation in the presence of Klebsiella pneumoniae induces necrotizing enterocolitis (NEC)-like injury in the small intestine of immature mice

SUMMARY Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in premature infants. During NEC pathogenesis, bacteria are able to penetrate innate immune defenses and invade the intestinal epithelial layer, causing subsequent inflammation and tissue necrosis. Normally, Paneth...

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Bibliographic Details
Main Authors: Chunxian Zhang, Michael P. Sherman, Lawrence S. Prince, David Bader, Jörn-Hendrik Weitkamp, James C. Slaughter, Steven J. McElroy
Format: Article
Language:English
Published: The Company of Biologists 2012-07-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/5/4/522

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