A 2-oxa-spiro[5.4]decane scaffold displays neurotrophic, neurogenic and anti-neuroinflammatory activities with high potential for development as a versatile CNS therapeutic

A 2-oxa-spiro[5.4]decane scaffold displays neurotrophic, neurogenic and anti-neuroinflammatory activities with high potential for development as a versatile CNS therapeutic

Abstract Following our recent discovery of a new scaffold exhibiting significant neurotrophic and neurogenic activities, a structurally tweaked analogue, embodying a 2-oxa-spiro [5.4]decane framework, has been conceptualised and found to be more potent and versatile. It exhibits enhanced neurotrophi...

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Bibliographic Details
Main Authors: Pranav Chintamani Joshi, Ramesh Samineni, Dwaipayan Bhattacharya, Bommana Raghunath Reddy, Lenin Veeraval, Tapatee Das, Swati Maitra, Abhipradnya Bipin Wahul, Shailaja Karri, Srihari Pabbaraja, Goverdhan Mehta, Arvind Kumar, Sumana Chakravarty
Format: Article
Language:English
Published: Nature Publishing Group 2017-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-01297-z

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https://doi.org/10.1038/s41598-017-01297-z

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