Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems

Many types of cells release phospholipid membrane vesicles thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. Extracellular vesicles (EVs) carry various proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs), like a “message in a bottle...

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Main Authors:	Shin-ichiro Ohno, Gregor P. C. Drummen, Masahiko Kuroda
Format:	Article
Language:	English
Published:	MDPI AG 2016-02-01
Series:	International Journal of Molecular Sciences
Subjects:	exosome microvesicle extracellular vesicle dexosome outer membrane vesicle stem cell drug delivery system vaccine clinical trial
Online Access:	http://www.mdpi.com/1422-0067/17/2/172

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spelling	doaj-3b4766a2000f4163aac6e8f093f3e9742020-11-24T21:51:47ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-02-0117217210.3390/ijms17020172ijms17020172Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic SystemsShin-ichiro Ohno0Gregor P. C. Drummen1Masahiko Kuroda2Department of Molecular Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanCellular Stress and Ageing Program, Bionanoscience and Bio-Imaging Program, Bio & Nano-Solutions, D-33647 Bielefeld, GermanyDepartment of Molecular Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, JapanMany types of cells release phospholipid membrane vesicles thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. Extracellular vesicles (EVs) carry various proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs), like a “message in a bottle” to cells in remote locations. The encapsulated molecules are protected from multiple types of degradative enzymes in body fluids, making EVs ideal for delivering drugs. This review presents an overview of the potential roles of EVs as natural drugs and novel drug-delivery systems.http://www.mdpi.com/1422-0067/17/2/172exosomemicrovesicleextracellular vesicleexosomedexosomeouter membrane vesiclestem celldrug delivery systemvaccineclinical trial
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shin-ichiro Ohno Gregor P. C. Drummen Masahiko Kuroda
spellingShingle	Shin-ichiro Ohno Gregor P. C. Drummen Masahiko Kuroda Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems International Journal of Molecular Sciences exosome microvesicle extracellular vesicle exosome dexosome outer membrane vesicle stem cell drug delivery system vaccine clinical trial
author_facet	Shin-ichiro Ohno Gregor P. C. Drummen Masahiko Kuroda
author_sort	Shin-ichiro Ohno
title	Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
title_short	Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
title_full	Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
title_fullStr	Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
title_full_unstemmed	Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems
title_sort	focus on extracellular vesicles: development of extracellular vesicle-based therapeutic systems
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2016-02-01
description	Many types of cells release phospholipid membrane vesicles thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. Extracellular vesicles (EVs) carry various proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs), like a “message in a bottle” to cells in remote locations. The encapsulated molecules are protected from multiple types of degradative enzymes in body fluids, making EVs ideal for delivering drugs. This review presents an overview of the potential roles of EVs as natural drugs and novel drug-delivery systems.
topic	exosome microvesicle extracellular vesicle exosome dexosome outer membrane vesicle stem cell drug delivery system vaccine clinical trial
url	http://www.mdpi.com/1422-0067/17/2/172
work_keys_str_mv	AT shinichiroohno focusonextracellularvesiclesdevelopmentofextracellularvesiclebasedtherapeuticsystems AT gregorpcdrummen focusonextracellularvesiclesdevelopmentofextracellularvesiclebasedtherapeuticsystems AT masahikokuroda focusonextracellularvesiclesdevelopmentofextracellularvesiclebasedtherapeuticsystems
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Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems

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